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Table 3 Validation of the added genes based on different information sources. The P-value is calculated using hyper-geometric distribution.

From: Computational prediction of the osmoregulation network in Synechococcus sp. WH8102

Methods Number of recruited genes Differentially-expressed genes (false discovery rate ≤ 0.01) P-value
Initial model 27 9 5.24 × 10-7
Operon 24 4 1.44 × 10-2
Protein-protein interactions 16 1 0.48
Regulon prediction 41 3 0.23
Phylogenetic profile 13 1 0.42
Expanded model 114 15 3.44 × 10-5