Table 3 Relationship between the mutation status at domain V of every 23S rRNA gene and the level of resistance to linezolid and other antibiotics.
S. pneumoniae strains | 23S rDNA status in PCR fragment/transformant | No. of colonies tested | spr_ rrnaD | spr_ rrnaC | spr_ rrnaB | spr_ rrnaA | MIC LNZ (μg/ml) | MIC CHL (μg/ml) | MIC FFC (μg/ml) | MIC PCG (μg/ml) |
|---|---|---|---|---|---|---|---|---|---|---|
R6 | 4 | W | W | W | W | 0.5 | 3 | 1 | 0.023 | |
T-R623SrDNAR6M2 | G2576T/G2576T | 3 | M | W | W | W | 1 | 6 | 2 | 0.023 |
T-R623SrDNAR6M2 | G2576T/G2576T | 4 | M | W | W | M | 2 | 12 | 2 | 0.023 |
T-R623SrDNAR6M2 | G2576T/G2576T | 4 | M | M | W | M | 4 | 16 | 8 | 0.023 |
T-R623SrDNAR6M2 | G2576T/G2576T | 4 | M | M | M | M | 8 | 24 | 16 | 0.023 |
1974 | 4 | W | W | W | W | 1 | 3 | 2 | 0.023 | |
T-197423SrDNA1974M1 | G2576T/G2576T | 12 | M | M | M | M | 16 | 24 | 16 | 0.023 |