van Gils EJ, Veenhoven RH, Hak E, Rodenburg GD, Keijzers WC, Bogaert D, Trzcinski K, Bruin JP, van Alphen L, van der Ende, Sanders EA: Pneumococcal conjugate vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains. Jama. 304 (10): 1099-1106.
Farrell DJ, Mendes RE, Ross JE, Jones RN: Linezolid surveillance program results for 2008 (LEADER Program for 2008). Diagnostic microbiology and infectious disease. 2009, 65 (4): 392-403. 10.1016/j.diagmicrobio.2009.10.011.
Article
PubMed
Google Scholar
Farrell DJ, Mendes RE, Ross JE, Sader HS, Jones RN: LEADER Program Results for 2009: an Activity and Spectrum Analysis of Linezolid Using 6,414 Clinical Isolates from 56 Medical Centers in the United States. Antimicrobial agents and chemotherapy. 2011, 55 (8): 3684-3690. 10.1128/AAC.01729-10.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jones RN, Ross JE, Bell JM, Utsuki U, Fumiaki I, Kobayashi I, Turnidge JD: Zyvox Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008. Diagnostic microbiology and infectious disease. 2009, 65 (4): 404-413. 10.1016/j.diagmicrobio.2009.10.001.
Article
PubMed
Google Scholar
Zhanel GG, Adam HJ, Low DE, Blondeau J, Decorby M, Karlowsky JA, Weshnoweski B, Vashisht R, Wierzbowski A, Hoban DJ: Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007-2009 study. Diagnostic microbiology and infectious disease. 2011, 69 (3): 291-306. 10.1016/j.diagmicrobio.2010.10.025.
Article
CAS
PubMed
Google Scholar
Matassova NB, Rodnina MV, Endermann R, Kroll HP, Pleiss U, Wild H, Wintermeyer W: Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. Rna. 1999, 5 (7): 939-946. 10.1017/S1355838299990210.
Article
CAS
PubMed
PubMed Central
Google Scholar
Leach KL, Swaney SM, Colca JR, McDonald WG, Blinn JR, Thomasco LM, Gadwood RC, Shinabarger D, Xiong L, Mankin AS: The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria. Mol Cell. 2007, 26 (3): 393-402. 10.1016/j.molcel.2007.04.005.
Article
CAS
PubMed
Google Scholar
Wilson DN, Schluenzen F, Harms JM, Starosta AL, Connell SR, Fucini P: The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning. Proc Natl Acad Sci USA. 2008, 105 (36): 13339-13344. 10.1073/pnas.0804276105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vara Prasad JV: New oxazolidinones. Curr Opin Microbiol. 2007, 10 (5): 454-460. 10.1016/j.mib.2007.08.001.
Article
CAS
PubMed
Google Scholar
Wolter N, Smith AM, Farrell DJ, Schaffner W, Moore M, Whitney CG, Jorgensen JH, Klugman KP: Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrob Agents Chemother. 2005, 49 (8): 3554-3557. 10.1128/AAC.49.8.3554-3557.2005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mutnick AH, Enne V, Jones RN: Linezolid resistance since 2001: SENTRY Antimicrobial Surveillance Program. Ann Pharmacother. 2003, 37 (6): 769-774.
Article
CAS
PubMed
Google Scholar
Prystowsky J, Siddiqui F, Chosay J, Shinabarger DL, Millichap J, Peterson LR, Noskin GA: Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci. Antimicrob Agents Chemother. 2001, 45 (7): 2154-2156. 10.1128/AAC.45.7.2154-2156.2001.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsiodras S, Gold HS, Sakoulas G, Eliopoulos GM, Wennersten C, Venkataraman L, Moellering RC, Ferraro MJ: Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet. 2001, 358 (9277): 207-208. 10.1016/S0140-6736(01)05410-1.
Article
CAS
PubMed
Google Scholar
Meka VG, Gold HS: Antimicrobial resistance to linezolid. Clin Infect Dis. 2004, 39 (7): 1010-1015. 10.1086/423841.
Article
CAS
PubMed
Google Scholar
Meka VG, Pillai SK, Sakoulas G, Wennersten C, Venkataraman L, DeGirolami PC, Eliopoulos GM, Moellering RC, Gold HS: Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA. J Infect Dis. 2004, 190 (2): 311-317. 10.1086/421471.
Article
CAS
PubMed
Google Scholar
Hong T, Li X, Wang J, Sloan C, Cicogna C: Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation. J Clin Microbiol. 2007, 45 (10): 3277-3280. 10.1128/JCM.02048-06.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kelly S, Collins J, Maguire M, Gowing C, Flanagan M, Donnelly M, Murphy PG: An outbreak of colonization with linezolid-resistant Staphylococcus epidermidis in an intensive therapy unit. J Antimicrob Chemother. 2008, 61 (4): 901-907. 10.1093/jac/dkn043.
Article
CAS
PubMed
Google Scholar
Bongiorno D, Campanile F, Mongelli G, Baldi MT, Provenzani R, Reali S, Lo Russo C, Santagati M, Stefani S: DNA methylase modifications and other linezolid resistance mutations in coagulase-negative staphylococci in Italy. J Antimicrob Chemother. 65 (11): 2336-2340.
Bourgeois-Nicolaos N, Piriou O, Butel MJ, Doucet-Populaire F: [Linezolid: antibacterial activity, clinical efficacy and resistance]. Ann Biol Clin (Paris). 2006, 64 (6): 549-564.
CAS
Google Scholar
Gonzales RD, Schreckenberger PC, Graham MB, Kelkar S, DenBesten K, Quinn JP: Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet. 2001, 357 (9263): 1179-10.1016/S0140-6736(00)04376-2.
Article
CAS
PubMed
Google Scholar
Sinclair A, Arnold C, Woodford N: Rapid detection and estimation by pyrosequencing of 23S rRNA genes with a single nucleotide polymorphism conferring linezolid resistance in Enterococci. Antimicrob Agents Chemother. 2003, 47 (11): 3620-3622. 10.1128/AAC.47.11.3620-3622.2003.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marshall SH, Donskey CJ, Hutton-Thomas R, Salata RA, Rice LB: Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis. Antimicrob Agents Chemother. 2002, 46 (10): 3334-3336. 10.1128/AAC.46.10.3334-3336.2002.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ruggero KA, Schroeder LK, Schreckenberger PC, Mankin AS, Quinn JP: Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs. Diagn Microbiol Infect Dis. 2003, 47 (3): 511-513. 10.1016/S0732-8893(03)00153-6.
Article
CAS
PubMed
Google Scholar
Wilson P, Andrews JA, Charlesworth R, Walesby R, Singer M, Farrell DJ, Robbins M: Linezolid resistance in clinical isolates of Staphylococcus aureus. J Antimicrob Chemother. 2003, 51 (1): 186-188. 10.1093/jac/dkg104.
Article
CAS
PubMed
Google Scholar
Tsakris A, Pillai SK, Gold HS, Thauvin-Eliopoulos C, Venkataraman L, Wennersten C, Moellering RC, Eliopoulos GM: Persistence of rRNA operon mutated copies and rapid re-emergence of linezolid resistance in Staphylococcus aureus. J Antimicrob Chemother. 2007, 60 (3): 649-651. 10.1093/jac/dkm246.
Article
CAS
PubMed
Google Scholar
Besier S, Ludwig A, Zander J, Brade V, Wichelhaus TA: Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. Antimicrob Agents Chemother. 2008, 52 (4): 1570-1572. 10.1128/AAC.01098-07.
Article
CAS
PubMed
PubMed Central
Google Scholar
Locke JB, Hilgers M, Shaw KJ: Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother. 2009, 53 (12): 5265-5274. 10.1128/AAC.00871-09.
Article
CAS
PubMed
PubMed Central
Google Scholar
Locke JB, Hilgers M, Shaw KJ: Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob Agents Chemother. 2009, 53 (12): 5275-5278. 10.1128/AAC.01032-09.
Article
CAS
PubMed
PubMed Central
Google Scholar
Feng J, Lupien A, Gingras H, Wasserscheid J, Dewar K, Legare D, Ouellette M: Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009, 19 (7): 1214-1223. 10.1101/gr.089342.108.
Article
CAS
PubMed
PubMed Central
Google Scholar
Holzel CS, Harms KS, Schwaiger K, Bauer J: Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4. Antimicrob Agents Chemother. 54 (3): 1351-1353.
Farrell DJ, Morrissey I, Bakker S, Buckridge S, Felmingham D: In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations. Antimicrob Agents Chemother. 2004, 48 (8): 3169-3171. 10.1128/AAC.48.8.3169-3171.2004.
Article
CAS
PubMed
PubMed Central
Google Scholar
Toh SM, Xiong L, Arias CA, Villegas MV, Lolans K, Quinn J, Mankin AS: Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Molecular microbiology. 2007, 64 (6): 1506-1514. 10.1111/j.1365-2958.2007.05744.x.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bonilla H, Huband MD, Seidel J, Schmidt H, Lescoe M, McCurdy SP, Lemmon MM, Brennan LA, Tait-Kamradt A, Puzniak L, Quinn JP: Multicity outbreak of linezolid-resistant Staphylococcus epidermidis associated with clonal spread of a cfr-containing strain. Clin Infect Dis. 51 (7): 796-800.
Morales G, Picazo JJ, Baos E, Candel FJ, Arribi A, Pelaez B, Andrade R, de la Torre MA, Fereres J, Sanchez-Garcia M: Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus. Clin Infect Dis. 50 (6): 821-825.
Sanchez Garcia M, De la Torre MA, Morales G, Pelaez B, Tolon MJ, Domingo S, Candel FJ, Andrade R, Arribi A, Garcia N, Martínez Sagasti F, Fereres J, Picazo J: Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit. Jama. 303 (22): 2260-2264.
Livermore DM, Mushtaq S, Warner M, Woodford N: Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci. J Antimicrob Chemother. 2009, 63 (4): 713-715. 10.1093/jac/dkp002.
Article
CAS
PubMed
Google Scholar
Albert TJ, Dailidiene D, Dailide G, Norton JE, Kalia A, Richmond TA, Molla M, Singh J, Green RD, Berg DE: Mutation discovery in bacterial genomes: metronidazole resistance in Helicobacter pylori. Nature methods. 2005, 2 (12): 951-953. 10.1038/nmeth805.
Article
CAS
PubMed
Google Scholar
Andries K, Verhasselt P, Guillemont J, Gohlmann HW, Neefs JM, Winkler H, Van Gestel J, Timmerman P, Zhu M, Lee E, Williams P, de Chaffoy D, Huitric E, Hoffner S, Cambau E, Truffot-Pernot C, Lounis N, Jarlier V: A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science (New York, NY. 2005, 307 (5707): 223-227. 10.1126/science.1106753.
Article
CAS
Google Scholar
Charusanti P, Conrad TM, Knight EM, Venkataraman K, Fong NL, Xie B, Gao Y, Palsson BO: Genetic basis of growth adaptation of Escherichia coli after deletion of pgi, a major metabolic gene. PLoS genetics. 2010, 6 (11): e1001186-10.1371/journal.pgen.1001186.
Article
PubMed
PubMed Central
Google Scholar
Gao W, Chua K, Davies JK, Newton HJ, Seemann T, Harrison PF, Holmes NE, Rhee HW, Hong JI, Hartland EL, Stinear TP, Howden BP: Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection. PLoS pathogens. 2010, 6 (6): e1000944-10.1371/journal.ppat.1000944.
Article
PubMed
PubMed Central
Google Scholar
Manjunatha UH, Boshoff H, Dowd CS, Zhang L, Albert TJ, Norton JE, Daniels L, Dick T, Pang SS, Barry CE: Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2006, 103 (2): 431-436. 10.1073/pnas.0508392103.
Article
CAS
PubMed
Google Scholar
Mwangi MM, Wu SW, Zhou Y, Sieradzki K, de Lencastre H, Richardson P, Bruce D, Rubin E, Myers E, Siggia ED, Tomasz A: Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Proceedings of the National Academy of Sciences of the United States of America. 2007, 104 (22): 9451-9456. 10.1073/pnas.0609839104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lin AH, Murray RW, Vidmar TJ, Marotti KR: The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother. 1997, 41 (10): 2127-2131.
CAS
PubMed
PubMed Central
Google Scholar
Andersson DI: The biological cost of mutational antibiotic resistance: any practical conclusions?. Curr Opin Microbiol. 2006, 9 (5): 461-465. 10.1016/j.mib.2006.07.002.
Article
CAS
PubMed
Google Scholar
Balsalobre L, de la Campa AG: Fitness of Streptococcus pneumoniae fluoroquinolone-resistant strains with topoisomerase IV recombinant genes. Antimicrob Agents Chemother. 2008, 52 (3): 822-830. 10.1128/AAC.00731-07.
Article
CAS
PubMed
Google Scholar
Rozen DE, McGee L, Levin BR, Klugman KP: Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother. 2007, 51 (2): 412-416. 10.1128/AAC.01161-06.
Article
CAS
PubMed
Google Scholar
Trzcinski K, Thompson CM, Gilbey AM, Dowson CG, Lipsitch M: Incremental increase in fitness cost with increased beta -lactam resistance in pneumococci evaluated by competition in an infant rat nasal colonization model. J Infect Dis. 2006, 193 (9): 1296-1303. 10.1086/501367.
Article
CAS
PubMed
Google Scholar
Rieux V, Carbon C, Azoulay-Dupuis E: Complex relationship between acquisition of beta-lactam resistance and loss of virulence in Streptococcus pneumoniae. J Infect Dis. 2001, 184 (1): 66-72. 10.1086/320992.
Article
CAS
PubMed
Google Scholar
Marcusson LL, Frimodt-Moller N, Hughes D: Interplay in the selection of fluoroquinolone resistance and bacterial fitness. PLoS Pathog. 2009, 5 (8): e1000541-10.1371/journal.ppat.1000541.
Article
PubMed
PubMed Central
Google Scholar
Biedenbach DJ, Farrell DJ, Mendes RE, Ross JE, Jones RN: Stability of linezolid activity in an era of mobile oxazolidinone resistance determinants: results from the 2009 Zyvox(R) Annual Appraisal of Potency and Spectrum program. Diagn Microbiol Infect Dis. 68 (4): 459-467.
Mendes RE, Deshpande LM, Farrell DJ, Spanu T, Fadda G, Jones RN: Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy. J Antimicrob Chemother. 65 (11): 2329-2335.
Locke JB, Morales G, Hilgers M, G CK, Rahawi S, Jose Picazo J, Shaw KJ, Stein JL: Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. Antimicrob Agents Chemother. 54 (12): 5352-5355.
Ban N, Nissen P, Hansen J, Moore PB, Steitz TA: The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Science. 2000, 289 (5481): 905-920. 10.1126/science.289.5481.905.
Article
CAS
PubMed
Google Scholar
Harms J, Schluenzen F, Zarivach R, Bashan A, Gat S, Agmon I, Bartels H, Franceschi F, Yonath A: High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. Cell. 2001, 107 (5): 679-688. 10.1016/S0092-8674(01)00546-3.
Article
CAS
PubMed
Google Scholar
Kehrenberg C, Schwarz S, Jacobsen L, Hansen LH, Vester B: A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol. 2005, 57 (4): 1064-1073. 10.1111/j.1365-2958.2005.04754.x.
Article
CAS
PubMed
Google Scholar
Robertson GT, Doyle TB, Lynch AS: Use of an efflux-deficient streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents. Antimicrob Agents Chemother. 2005, 49 (11): 4781-4783. 10.1128/AAC.49.11.4781-4783.2005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marrer E, Schad K, Satoh AT, Page MG, Johnson MM, Piddock LJ: Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2006, 50 (2): 685-693. 10.1128/AAC.50.2.685-693.2006.
Article
CAS
PubMed
PubMed Central
Google Scholar
Garvey MI, Baylay AJ, Wong RL, Piddock LJ: Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother. 55 (1): 190-196.
Palmer AC, Angelino E, Kishony R: Chemical decay of an antibiotic inverts selection for resistance. Nat Chem Biol. 6 (2): 105-107.
Tomasz A, Hotchkiss RD: Regulation of the Transformability of Pheumococcal Cultures by Macromolecular Cell Products. Proc Natl Acad Sci USA. 1964, 51: 480-487. 10.1073/pnas.51.3.480.
Article
CAS
PubMed
PubMed Central
Google Scholar