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Table 2 Selected GOa biological process classifications of proteins differentially expressed in HCAECs following cold-adaptation.

From: Proteomic analysis of endothelial cold-adaptation

# of Proteins      
UP DN Ratiob %c Gene ontology categories P-Valued Folde
34 67 -2.0 56.7 Primary metabolic process 1.4 × 10-3 1.1
22 65 -3.0 48.9 Macromolecule metabolic process 1.9 × 10-3 1.3
12 50 -4.2 34.8 Gene expression 3.0 × 10-6 1.7
13 47 -3.6 33.7 Biosynthetic process 1.7 × 10-3 1.4
15 6 2.5 11.8 Catabolic process 9.9 × 10-2 1.4
11 1 11.0 6.7 Glycolysis 5.1 × 10-12 21.6
7 59 -8.4 31.5 Protein metabolic process 3.9 × 10-5 1.7
2 16 -8.0 10.1 Macromolecular complex assembly 2.2 × 10-3 2.3
0 11 - ∞ 6.2 Ribonucleoprotein complex assembly 5.3 × 10-5 5.2
9 18 -2.0 15.2 RNA processing 1.1 × 10-9 4.2
8 11 -1.4 10.7 mRNA metabolic process 3.6 × 10-7 4.3
2 38 -19.0 22.5 Translation 2.8 × 10-28 10.2
5 11 -2.2 9.0 Intracellular transport 1.1 × 10-2 2.1
0 7 - ∞ 3.9 Protein folding 1.8 × 10-2 3.3
0 9 - ∞ 5.1 Unfolded protein bindingf 5.0 × 10-5 6.9
6 5 1.2 6.2 Cell proliferation 3.3 × 10-2 2.1
6 1 6.0 3.9 Anti-apoptosis 3.5 × 10-2 2.9
3 3 1.0 3.4 Structure-specific DNA binding 2.5 × 10-2 3.6
11 7 1.6 10.1 Cytoskeletal organization 1.5 × 10-5 3.5
13 4 3.2 9.6 Actin filament-based process 2.5 × 10-8 6.0
1 11 -11.0 6.7 Microtubule cytoskeletong 3.3 × 10-2 3.0
9 5 1.8 7.9 Oxidoreductase activityf 5.1 × 10-2 1.8
3 2 1.5 2.8 Cell redox homeostasis 6.4 × 10-3 6.7
11 16 -1.5 15.2 Response-to-stress 8.9 × 10-2 1.4
  1. Proteins were classified using the Gene Functional Annotation Tool of DAVID bioinformatics resources. a. Gene Ontology; b. Ratios are negative where the number of proteins down-regulated at 25°C (# DN) > the number of proteins up-regulated at 25°C (# UP) and positive where # UP > # DN; c. % = the number of proteins in this category out of 178 proteins; d. Modified Fisher Exact P-value (probability of obtaining this many differentially expressed proteins in the category by chance); e. Fold-enrichment; f. GO Molecular Function term. g. GO Cellular Component term.