Comparative genomics allowed the identification of drug targets against human fungal pathogens

BMC Genomics

Table 1 Potential target genes selected for new antifungal drug development

Gene	Biological process	Cytolocalization	PDB template	Organism	E-value	PDB sequence identidy (%)
trr1	Cell redox homeostasis	Cytoplasm	1ITJ	Saccharomyces cerevisiae	3e-115	65
			1VDC	Arabidopsis thaliana	1e-94	57
aur1	Cellular metabolism	Golgi and membrane	*	*	*	*
mak5	Ribosome biogenesis	Nucleolus	1HV8	Methanocaldococcus jannaschii	7e-42	30
chs1	Cell wall biogenesis/degradation	Membrane	*	*	*	*
tom40	Protein transport	Mitochondrion membrane	2QK9	Homo sapiens	0.8	34
kre6	Cell wall biogenesis/degradation	Golgi apparatus Membrane	2VY0	Pyrococcus furiosus	6e-4	32
fks1	Cell wall organization/biogenesis	Membrane	1R1M	Neisseria meningitidis	0.3	32
kre2	Protein mannosilation	Golgi membrane	1S4N	Saccharomyces cerevisiae	6e-96	50
erg6	Ergosterol biosynthesis	Endoplasmatic reticulum membrane	3BUS	Lechevalieria aerocolonigenes	5e-18	32
rim8	pH-response regulator	Cytoplasm	3G3L	Bacteroides fragilis	3,9	38

ISSN: 1471-2164