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Table 1 Potential target genes selected for new antifungal drug development

From: Comparative genomics allowed the identification of drug targets against human fungal pathogens

Gene Biological process Cytolocalization PDB template Organism E-value PDB sequence identidy (%)
trr1 Cell redox homeostasis Cytoplasm 1ITJ Saccharomyces cerevisiae 3e-115 65
    1VDC Arabidopsis thaliana 1e-94 57
aur1 Cellular metabolism Golgi and membrane * * * *
mak5 Ribosome biogenesis Nucleolus 1HV8 Methanocaldococcus jannaschii 7e-42 30
chs1 Cell wall biogenesis/degradation Membrane * * * *
tom40 Protein transport Mitochondrion membrane 2QK9 Homo sapiens 0.8 34
kre6 Cell wall biogenesis/degradation Golgi apparatus Membrane 2VY0 Pyrococcus furiosus 6e-4 32
fks1 Cell wall organization/biogenesis Membrane 1R1M Neisseria meningitidis 0.3 32
kre2 Protein mannosilation Golgi membrane 1S4N Saccharomyces cerevisiae 6e-96 50
erg6 Ergosterol biosynthesis Endoplasmatic reticulum membrane 3BUS Lechevalieria aerocolonigenes 5e-18 32
rim8 pH-response regulator Cytoplasm 3G3L Bacteroides fragilis 3,9 38
  1. * Structure absent in PDB (http://www.rcsb.org/pdb/home/home.do)