Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation

Table 1 Enriched functional gene clusters for each list of significant genes inferred using DAVID

Functional enrichment clusters
All significant genes	Score	Forewing	Score
structural constituent of cuticle	9.61	structural constituent of cuticle	9.19
chitin binding	2.43	cytoskeleton/muscle	1.26
pigmentation	1.44	redox activity	1.21
aging	1.41	Immunoglobulin-like	1.17
muscle related	1.16	oxidative response	1.03
thioredoxin; oxidoreductase	1.16	ribosomal	1.02
ATP nucleotide binding	1.15	motor activity	0.93
metal binding	0.89	Aging, response to oxidative stress	0.93
oxidative response	0.88
hormone receptor	0.87	Hindwing
growth	0.84	structural constituent of cuticle	2.23
cellular localization	0.83	chitin binding	2.04
homedomain related	0.80	pigmentation	1.94
GTP related	0.71	visual perception and cognition	0.78
cytoskeleton	0.71	metal binding	0.78
intrinsic to plasma membrane	0.70	intrinsic to transmembrane	0.58
hormone and odorant binding	0.69	GTP related	0.55
immune response	0.67
carboxypeptidase activity	0.65	Proximal-Distal
motor activity	0.67	structural constituent of cuticle	9.55
serine-type peptidase activity	0.59	extracellular matrix and cell adhesion	2.95
biogenic amine metabolic process	0.55	morphogenesis/transcription factors	2.23
		immunoglobulin-like	1.61
Color-Specific		chitin binding	1.29
structural constituent of cuticle	1.96	cytoskeleton/muscle	1.16
		notch signaling pathway	1.05
		zinc-finger and ion binding	0.72

Category names are a summary of all gene ontology terms assigned to a functional gene cluster using the gene functional classification tool in DAVID. Only functional classes with scores greater than 0.50 are displayed.

ISSN: 1471-2164