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Table 2 Gene function enrichment analysis of B. pseudomallei common up-regulated and down-regulated genes throughout growth within host macrophages

From: Burkholderia pseudomallei transcriptional adaptation in macrophages

Functional class or pathway No. of genes regulated No. of genes in genome Significance (p- value)
Up-regulated genes    
Benzoate degradation via hydroxylation 3 29 3.33 × 10-2
Down-regulated genes    
Amino sugar and nucleotide sugar metabolism 22 39 7.98 × 10-10
Bacterial chemotaxis 23 46 2.65 × 10-9
Lipopolysaccharide biosynthesis 13 24 2.36 × 10-5
Peptidoglycan biosynthesis 11 24 7.93 × 10-4
Flagella assembly 11 38 2.72 × 10-2
Alanine, aspartate and glutamate metabolism 15 32 2.41 × 10-5
Fatty acid biosynthesis 9 21 6.33 × 10-3
Two-component system 30 104 3.68 × 10-6
Glycolysis/gluconeogenesis 11 36 1.81 × 10-2
Oxidative phosphorylation 15 60 1.55 × 10-2