Skip to main content

Table 7 Novel deleterious mutations specific to SAMP8/TaSlc

From: Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

Location Gene symbol Gene name Nucleotide change (cDNA) Amino acid change SIFT score Polyphen-2 score
Chr2:60190230 Ly75 lymphocyte antigen 75 c.1657G>A p.R553W 0.02 0.997
Chr5:75023400 Lnx1 ligand of numb-protein X 1 c.685T>A p.N154Y 0 0.318
Chr15:34358663 Matn2 matrilin 2 c.2668C>T p.A806V 0.01 0.717
Chr16:14195230 Myh11 myosin, heavy polypeptide 11, smooth muscle c.5938C>T p.R1945H 0.17 0.99
Chr16:17506416 Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 c.1966G>T p.K582N 0.01 0.879