The complex regulatory networks of NATs. In the NAT regulatory networks genes may form cis- and trans-NATs. Some NATs may fold into the hairpin structure characteristic of pre-miRNAs, and generate miRNAs; some NATs may give rise to nat-siRNAs. The nat-siRNAs can self-regulate the expression of NAT sense or antisense transcripts, and they can target other genes. Additionally, many miRNA targets may be involved in the formation of NATs.