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Table 3 MiRNAs with expression and/or function related to brain or nervous system

From: miRNA and miRNA target genes in copy number variations occurring in individuals with intellectual disability

#Chr Start (bp) End (bp) miRNA ID CNV feature Expression* Functional relevance** Reference
1 1103258 1103279 hsa-miR-200a/b de novo hsa-pancreatic islets, hsa-breast adenocarcinoma, HT29, breast malignant tumor olfactory neurogenesis; neuronal differentiation of neural stem/progenitor cells PMID:18184563; PMID: 22993445
1 1104435 1104456 hsa-miR-429 de novo cancer-related non-brain cancer related; neuroprotective effect in in vitro ischemia PMID: 21684154; PMID: 20576953
5 87962684 87962705 hsa-miR-9 de novo brain, astrocytoma, neuroblastoma Upregulation in HD (Huntington’s disease); involved in spinal motor neuron disease; increased in fmr1/fxr2 knock-out mice PMID: 19118166; PMID: 20616011 PMID:21957233
5 179442361 179442382 hsa-miR-340 de novo neuroblastoma cancer-related including neuroblastoma PMID: 22797059
7 99691233 99691253 hsa-miR-25 de novo neuroblastoma neural stem cells differentiation PMID: 21386132
7 99691438 99691460 hsa-miR-93 de novo cervix-Hela neural stem cells differentiation PMID: 21386132
7 99691625 99691646 hsa-miR-106b de novo Neurobl-SHSY5Y_IFN, AML-THP1, kidney-embryo-HEK2 neuronal differentiation; pathogenesis of Alzheimer’s diseases PMID: 21386132; PMID: 20709030
19 4770712 4770734 hsa-miR-7 de novo neuroblastoma Repression of alpha-synuclein accumaulation in Parkinson’s disease; brain cancers PMID: 20106983; PMID: 21912681
20 61151558 61151579 hsa-miR-1 de novo heart, thyroid, Ewing-sarcoma muscle development; modulating neurite outgrowth PMID: 22365735; PMID: 21170745
20 61809866 61809887 hsa-miR-124 de novo hsa-hippocamp-adult, hsa-celebellum-adult neuronal differentiation and incorporation of neural-specific exons; increased in fmr1/fxr2 knock-out mice PMID: 17679093 PMID:21957233
1 94312436 94312455 hsa-miR-760 familial hsa-Neurobl-SHSY5Y, hsa-Hodgkin-KMH2, hsa-midbrain-adult non-brain cancer related PMID: 22970209
15 45725296 45725317 hsa-miR-147b familial hsa-fibrobl-CMV, hsa-medullobl-DADY, hsa-DLBCL-DLBL3, dendritic cel l rectal cancer-specific PMID: 22850566
2 32757280 32757298 hsa-miR-558 common-case ovary and ovary-related cancer cancer-related including neuroblastoma PMID: 21498633
  1. Notes: *indicates data collected from websites: http://www.microrna.org/microrna/ and mimiRNa (http://mimirna.centenary.org.au/mep/mir.htm).
  2. **indicate manual PubMed search for each miRNA.
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BMC Genomics

ISSN: 1471-2164

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