Table 3 MiRNAs with expression and/or function related to brain or nervous system
#Chr | Start (bp) | End (bp) | miRNA ID | CNV feature | Expression* | Functional relevance** | Reference |
|---|---|---|---|---|---|---|---|
1 | 1103258 | 1103279 | hsa-miR-200a/b | de novo | hsa-pancreatic islets, hsa-breast adenocarcinoma, HT29, breast malignant tumor | olfactory neurogenesis; neuronal differentiation of neural stem/progenitor cells | PMID:18184563; PMID: 22993445 |
1 | 1104435 | 1104456 | hsa-miR-429 | de novo | cancer-related | non-brain cancer related; neuroprotective effect in in vitro ischemia | PMID: 21684154; PMID: 20576953 |
5 | 87962684 | 87962705 | hsa-miR-9 | de novo | brain, astrocytoma, neuroblastoma | Upregulation in HD (Huntington’s disease); involved in spinal motor neuron disease; increased in fmr1/fxr2 knock-out mice | PMID: 19118166; PMID: 20616011 PMID:21957233 |
5 | 179442361 | 179442382 | hsa-miR-340 | de novo | neuroblastoma | cancer-related including neuroblastoma | PMID: 22797059 |
7 | 99691233 | 99691253 | hsa-miR-25 | de novo | neuroblastoma | neural stem cells differentiation | PMID: 21386132 |
7 | 99691438 | 99691460 | hsa-miR-93 | de novo | cervix-Hela | neural stem cells differentiation | PMID: 21386132 |
7 | 99691625 | 99691646 | hsa-miR-106b | de novo | Neurobl-SHSY5Y_IFN, AML-THP1, kidney-embryo-HEK2 | neuronal differentiation; pathogenesis of Alzheimer’s diseases | PMID: 21386132; PMID: 20709030 |
19 | 4770712 | 4770734 | hsa-miR-7 | de novo | neuroblastoma | Repression of alpha-synuclein accumaulation in Parkinson’s disease; brain cancers | PMID: 20106983; PMID: 21912681 |
20 | 61151558 | 61151579 | hsa-miR-1 | de novo | heart, thyroid, Ewing-sarcoma | muscle development; modulating neurite outgrowth | PMID: 22365735; PMID: 21170745 |
20 | 61809866 | 61809887 | hsa-miR-124 | de novo | hsa-hippocamp-adult, hsa-celebellum-adult | neuronal differentiation and incorporation of neural-specific exons; increased in fmr1/fxr2 knock-out mice | PMID: 17679093 PMID:21957233 |
1 | 94312436 | 94312455 | hsa-miR-760 | familial | hsa-Neurobl-SHSY5Y, hsa-Hodgkin-KMH2, hsa-midbrain-adult | non-brain cancer related | PMID: 22970209 |
15 | 45725296 | 45725317 | hsa-miR-147b | familial | hsa-fibrobl-CMV, hsa-medullobl-DADY, hsa-DLBCL-DLBL3, dendritic cel l | rectal cancer-specific | PMID: 22850566 |
2 | 32757280 | 32757298 | hsa-miR-558 | common-case | ovary and ovary-related cancer | cancer-related including neuroblastoma | PMID: 21498633 |