CNV category | No. of coding genes in CNVs | Genes in CNVs targeted by miRNA | Pathways enriched for miRNA target genes | miRNA targeting the genes in CNVs in enrichment analysis |
---|---|---|---|---|
De novo from ID | 737 | 84 (11.5%)a | MAPK signaling pathway | MIR-128A,MIR-128B,MIR-194,MIR-27A,MIR-27B,MIR-296,MIR-302A,MIR-302B,MIR-302C,MIR-302D,MIR-326,MIR-329,MIR-34A,MIR-34C,MIR-372,MIR-373,MIR-449,MIR-503,MIR-520A,MIR-520B,MIR-520C,MIR-520D,MIR-520E,MIR-526B,MIR-9,MIR-93 |
Lysosome | ||||
Insulin signaling pathway | ||||
Axon guidance | ||||
Huntington’s disease | ||||
Hedgehog signaling pathway | ||||
Endocytosis | ||||
N-Glycan biosynthesis | ||||
p53 signaling pathway | ||||
Progesterone-mediated oocyte maturation | ||||
Pathogenic from Decipher | 838 | 87 (10.4%)a | Neurotrophin signaling pathway | MIR-196A,MIR-196B,MIR-24,MIR-320,MIR-506,MIR-493,MIR-25,MIR-32,MIR-92,MIR-363,MIR-367,MIR-512-5P,MIR-302C,MIR-30A-5P,MIR-30C,MIR-30D,MIR-30B,MIR-30E-5P,MIR-485-3P |
Renal cell carcinoma | ||||
MAPK signaling pathway | ||||
Pathways in cancer | ||||
Chronic myeloid leukemia | ||||
Chemokine signaling pathway | ||||
Long-term potentiation | ||||
ErbB signaling pathway | ||||
TGF-beta signaling pathway | ||||
Adherens junction | ||||
Familial from ID | 188 | 15 (8.1%)a | Ubiquitin mediated proteolysis | MIR-193A,MIR-193B,MIR-495,MIR-302C,MIR-198 |
Common from ID case cohort | 454 | 0b | N/A | 0 |
Common from control cohort | 266 | 3 (1.1%)b | N/A | MIR-526B |