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Table 4 Summary of miRNA target genes within the CNV subgroups and the miRNAs targeting the CNV genes

From: miRNA and miRNA target genes in copy number variations occurring in individuals with intellectual disability

CNV category

No. of coding genes in CNVs

Genes in CNVs targeted by miRNA

Pathways enriched for miRNA target genes

miRNA targeting the genes in CNVs in enrichment analysis

De novo from ID

737

84 (11.5%)a

MAPK signaling pathway

MIR-128A,MIR-128B,MIR-194,MIR-27A,MIR-27B,MIR-296,MIR-302A,MIR-302B,MIR-302C,MIR-302D,MIR-326,MIR-329,MIR-34A,MIR-34C,MIR-372,MIR-373,MIR-449,MIR-503,MIR-520A,MIR-520B,MIR-520C,MIR-520D,MIR-520E,MIR-526B,MIR-9,MIR-93

Lysosome

Insulin signaling pathway

Axon guidance

Huntington’s disease

Hedgehog signaling pathway

Endocytosis

N-Glycan biosynthesis

p53 signaling pathway

Progesterone-mediated oocyte maturation

Pathogenic from Decipher

838

87 (10.4%)a

Neurotrophin signaling pathway

MIR-196A,MIR-196B,MIR-24,MIR-320,MIR-506,MIR-493,MIR-25,MIR-32,MIR-92,MIR-363,MIR-367,MIR-512-5P,MIR-302C,MIR-30A-5P,MIR-30C,MIR-30D,MIR-30B,MIR-30E-5P,MIR-485-3P

Renal cell carcinoma

MAPK signaling pathway

Pathways in cancer

Chronic myeloid leukemia

Chemokine signaling pathway

Long-term potentiation

ErbB signaling pathway

TGF-beta signaling pathway

Adherens junction

Familial from ID

188

15 (8.1%)a

Ubiquitin mediated proteolysis

MIR-193A,MIR-193B,MIR-495,MIR-302C,MIR-198

Common from ID case cohort

454

0b

N/A

0

Common from control cohort

266

3 (1.1%)b

N/A

MIR-526B

  1. Notes: Significant difference was found between data a and data b (P < 0.05) (a two sided Fisher’s exact test). N/A: not available.