Figure 9

Proposed regulatory network in exoskeleton construction. Potential regulatory network acting in the thoracic dorsum based on shared overrepresented motifs in the UCR regions of CP- and muscle-related genes. CP- and muscle-related genes integrating the network were all up regulated during adult exoskeleton formation. Rectangles show transcription factors and the target sequences (motif logos) in the UCR regions (see Additional file 7: Table S6). Red and green circles represent the CP- and muscle-related genes, respectively. The arrows indicate the occurrence of motifs in the UCRs of target genes. See Additional file 6: Table S5 for GB accession numbers and other information on these CP genes. Muscle-related genes: Wnt2 (GB16243), Bt (GB11358), Mlp60A (GB19606), Up (GB16881), TpnC73F (GB10545), Mhc (GB30329), mGluRA (GB18621), Tm1 (GB30512), Mf (GB12239), Mlc1 (GB16215), sqh (GB17693), Mlc2 (GB13399), Prm (GB30222), Mhcl (GB12303), Strn-Mlck (GB16909), zip (GB18651), sls (GB14642), Zyx (GB15339), Neurochondrin (GB14786), coro (GB20076), Scp2 (GB15916). See Additional file 3: Table S3 and Additional file 4: Table S4 for information on identity and potential function of muscle-related genes.