Table 3 Genes involved in detoxification having an eQTL
Name | eQTL | |||||
|---|---|---|---|---|---|---|
Standard | Systematic | Localization a | Lod score | Regulation b | Venn group | SGD Function |
Ions Detoxification | ||||||
MNR2 | YKL064W | chr2:151 | 4,49 | unknown | 23 | Putative magnesium transporter; has similarity to Alr1p and Alr2p which mediate influx of Mg2+ and other divalent cations |
ALR2 | YFL050C | chr6:30 | 5,88 | Self | 123 | Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition |
SSU1 | YPL092W | chr16:371 | 5,92 | Self | 123 | Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein |
Drug Transport | ||||||
TPO2 | YGR138C | chr7:761 | 17,28 | Self | 123 | Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily |
SNG1 | YGR197C | chr15:639 | 5,24 | YRR1 | 1 | Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance |
ERC1 | YHR032W | chr2:624 | 4,09 | unknown | 13 | Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily |
PDR11 | YIL013C | chr12:659 | 4,78 | HAP1/PDR8 | 123 | ATP-binding cassette (ABC) transporter multidrug transporter involved in MDR; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p |
QDR2 | YIL121W | chr12:680 | 10,31 | HAP1/PDR8 | 123 | Multidrug transporter of the major facilitator superfamily required for resistance to quinidine barban cisplatin and bleomycin; may have a role in potassium uptake |
GEX2 | YKR106W | chr11:658 | 13,66 | Self | 123 | Proton:glutathione antiporter localized to the vacuolar and plasma membranes; almost identical to paralog Gex1p; potential role in resistance to oxidative stress |
TPO1 | YLL028W | chr12:86 | 9,89 | Self | 123 | Polyamine transporter that recognizes spermine putrescine and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH |
TPO4 | YOR273C | chr12:659 | 4,61 | HAP1/PDR8 | 13 | Polyamine transport protein recognizes spermine putrescine and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily |
PDR12 | YPL058C | chr13:116 | 7,50 | WAR1 | 123 | Plasma membrane ATP-binding cassette (ABC) transporter weak-acid-inducible multidrug transporter required for weak organic acid resistance; regulated by War1p |
Transcription factor | ||||||
HAP1 | YLR256W | chr12:673 | 6,22 | Self | 123 | Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen |
PDR8 | YLR266C | chr16:138 | 5,00 | unknown | 2 | Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the PDR phenomenon |
WAR1 | YML076C | chr12:673 | 6,57 | HAP1/PDR8 | 123 | Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34 |
YRR1 | YOR162C | chr15:639 | 5,03 | Self | 13 | Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p acting on an overlapping set of target genes |
FZF1 | YGL254W | chr7:21 | 4,02 | Self | 123 | Transcription factor involved in sulfite metabolism, identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity |
Other/Unknown | ||||||
SVS1 | YPL163C | chr16:251 | 9,55 | Self | 123 | Cell wall and vacuolar protein required for wild-type resistance to vanadate |
YKR104W | YKR104W | chr11:651 | 4,63 | Self | 13 | Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C |
YLR046C | YLR046C | chr12:238 | 5,72 | Self | 123 | Putative membrane protein transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance |
YJL216C | YJL216C | chr10:42 | 11,36 | Self | 123 | Protein of unknown function similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p along with other genes involved in the PDR phenomenon |
YLR179C | YLR179C | chr12:689 | 4,08 | HAP1/PDR8 | 23 | Protein of unknown function transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; not essential |