Figure 4

An overview of the prioritized genes from mouse QTLs. (a) A total of 258 genes (winners) were ranked at the top 10% in each QTL region by the seed- (RWR, sHKDR) or DE-based method (deHKDR). The numbers of winners identified by one, two, or all three methods are shown in a Venn diagram. The winners identified by at least one of the seed-based methods and by the DE-based method were termed 2-strategy winners. The remaining winners (identified by the seed-based methods only or by DE-based method only) were termed single-strategy winners. (b) 2-strategy winners are better supported by the genetic or functional evidence compared with single-strategy winners. Each set of winners(2-strategy winners, DE-only winners, seed-only winners) was annotated by genetic evidence and functional evidence. The proportion of winners supported by one class of evidence or both was plotted as a stacked cylinder. One-tailed hypergeometric test was used to determine the enrichment significance of the supported winners (either supported by genetic or functional evidences) in a winner set, given all prioritized winners as background. P values were annotated above the corresponding cylinders.