Table 2 Affected hematopoiesis-associated signaling pathways in Rpl11-deficient zebrafish embryos at 48 hpf
Ingenuity canonical pathways | -log (p-value) | Up/down regulation | Functions | Reference |
|---|---|---|---|---|
Wnt/β-catenin signaling | 3.81E + 00 | Down | HSC formation, self-renewal, and differentiation | |
Aryl hydrocarbon receptor signaling | 3.70E + 00 | Down | Maintenance of HSC quiescence | [49] |
IGF-1 signaling | 4.28E + 00 | Up | Regulation of hematopoiesis and proliferation of hematopoietic stem cell progenitor cells | |
IL-17A signaling in fibroblasts | 4.27E + 00 | Up | Linking T cell function and hematopoiesis, mediating the hematopoietic response | [43] |
Glucocorticoid receptor signaling | 3.67E + 00 | Up | Stimulation of BFU-E progenitor self-renewal and regulation of stress erythropoiesis |