Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing

Table 3 Summary of affected iron metabolism-related genes in Rpl11-deficient zebrafish embryos

Zebrafish gene	Fold change	Functions	Hematopoiesis-associated phenotypes	Human homolog	Reference
alas2	↓1.44	First enzyme of heme synthesis	X-linked sideroblastic anemia	ALAS2	[51]
tfa	↓1.89	Fe(III)-carrier in plasma	Severe anemia	TF	[52]
tfr1b	↓2.75	Membrane receptor for Fe(II)-TF	Embryonic lethality and hematopoietic defect	TFRC	[53]
aco2	↓1.3	Bind to IREs; Fe sensors	Microcytic anemia	IRP2	[54]
fth1a	↓1.35	Prevents Fe toxicity during erythropoiesis	Embryonic lethality	FTH1	[55, 56]
fth1b	↓1.83	Prevents Fe toxicity during erythropoiesis	Embryonic lethality	FTH1	[55, 56]
slc25a37	↓1.77	Iron transport into mitochondria	Embryonic lethal with profound anemia; hypochromic anemia	SLC25A37	[57, 58]
cp	↓2.88	Oxidizes exported Fe2+	Hypochromic microcytic anemia	CP	[59]
htt	↓1.27	Transferrin receptor trafficking	Hypochromic anemia	HTT	[60]
sfxn1	↓2.19	Mitochondrial transport and iron metabolism	Siderocytic anemia	SFXN1	[61]
zgc:194125	↑2.73	Iron homeostasis and heme synthesis	Sideroblastic anemia	FTMT	[37, 62]
zgc:109934	↑2.36	Iron homeostasis and heme synthesis	Sideroblastic anemia	FTMT	[37, 62]
zgc:173594	↑4.12

The arrow up and down respectively stand for up- and down-regulation of genes in Rpl11-deficient zebrafish embryos.

ISSN: 1471-2164