Figure 4From: Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatinMorphemes in DNA fragments that interact with MLL1 in DNA binding and functional assays. (A) Sequences analyzed in DNA binding or transient expression assays. Probe 1 corresponded to insert 1, shown in Figure 2A; probe 2 was derived from the HSV TK promoter [53]. Colored sequences highlight the position of MLL1 morphemes in probe 1 and probe 2 (B) MLL1 morphemes in a DNA segment from the mouse Hoxa9 gene. This segment includes the promoter of a Hoxa9 transcript [54]. Colored sequences highlight CpG-rich clusters that in vivo MLL1 protected from methylation [54]. Color-coding follows the scheme in Figure 2B.Back to article page