Figure 9

Protein domains in vertebrate PDX1 and PDX2. Transactivation domains A-E[119], PCIF1-interaction domains [118], homeodomains, DNA-binding domains (i) and nuclear localisation signals (ii) are highlighted. Domain E contains the PBX-interacting hexapeptide motif [117]. There is very little conservation of amino acid sequence between the paralogous PDX1 and PDX2 suggesting that they carry out distinct functions within the pancreas, although clearly both are localised to the nucleus, bind DNA and interact with PBX proteins. Hsa, human (Homo sapiens); Mmu, mouse (Mus musculus); Rno, rat (Rattus norvegicus); Gga, chicken (Gallus gallus); Acar, Anole lizard (Anolis carolinensis); Xla, Xenopus laevis; Xtr, Xenopus tropicalis; Lme, Indonesian coelacanth (Latimeria menadoensis); Lch, African coelacanth (Latimeria chalumnae); Acal, Bowfin (Amia calva); Loc, Spotted gar (Lepisosteus oculatus); Dre, zebrafish (Danio rerio); Tru, fugu (Takifugu rubripes); Ola, medaka (Oryzias latipes); Gac, stickleback; Tni, Green spotted puffer (Tetraodon nigroviridis); Sca, lesser spotted catshark (Scyliorhinus canicula); Ler, little skate (Leucoraja erinacea); Cmi, elephant shark (Callorhinchus milii); Bfl, amphioxus (Branchiostoma floridae).