Figure 8

Example of differentially expressed clusters for the comparison between the HeLa and THP-1 cells. An Example of differentially expressed clusters was represented by the UCSC Genome Browser [36] provided by the original Paraclu and RECLU. Clusters annotated to P2RY6 gene in chromosome 11 on the RefSeq hg18 genome. Each stacked track shows consistent genomic features. The track at the top shows the location of these clusters. Below this, the next track in purple shows the peaks annotated to P2RY6 identified the original Paraclu. A black cluster indicates that the cluster is not significantly differentially expressed or < 2.0 absolute log fold change. The third track from the top emphasized in orange indicates the 15 top peaks annotated to P2RY6. Three down-regulated peaks, highly expressed peaks for the THP-1 cells compared with the HeLa cells, of them are represented in orange and the log fold changes at the left of these clusters are negative values. Green bars indicate up-regulated clusters. Likewise, the bottom peak around the transcription start sites of P2RY6 emphasized in blue is shown below. Since the peak was not significantly differentially expressed or < 2.0 absolute log fold change, the bar with chevrons is represented in black. TPM for HeLa and TPM for THP-1 tracks below this show the mean TPM among replicates at each site for HeLa and THP-1 cells, respectively. The following tracks indicate genomic information for P2RY6 based on the UCSC database [23].