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Table 3 Enrichment of gene groups down-regulated in muscle-less humeri based on GO terms under subontologies biological process and cellular component

From: Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

Gene ontology term Gene count in study Enrichment1
Development/Differentiation 155 2.73 × 10-15 to 0.0084
  GO:0048856: Anatomical structure development 134 2.73 × 10-15
GO:0032502: Developmental process 155 1.52 × 10-14
GO:0048513: Organ development 107 4.23 × 10-13
GO:0007275: Multicellular organismal development 142 4.92 × 10-13
GO:0048731: System development 122 5.57 × 10-13
GO:0009888: Tissue development 58 8.37 × 10-13
GO:0030154: Cell differentiation 94 8.86 × 10-10
GO:0048869: Cellular developmental process 96 1.67 × 10-9
GO:0048468: Cell development 45 2.66 × 10-7
GO:0009887: Organ morphogenesis 38 6.12 × 10-5
GO:0001756: Somitogenesis 8 2.61 × 10-4
GO:0035282: Segmentation 9 2.66 × 10-4
GO:0009952: Anterior/posterior pattern formation 13 0.0033
GO:0009790: Embryonic development 34 0.0074
GO:0043009: Chordate embryonic development 24 0.0075
GO:0009792: Embryonic development ending in birth 24 0.0084
Cytoskeleton 30 5.30 × 10-19 to 0.0995
  Biological process GO:0030029: Actin filament-based process 25 1.45 × 10-9
GO:0030036: Actin cytoskeleton organization 23 1.08 × 10-8
GO:0007010: Cytoskeleton organization 31 1.50 × 10-7
GO:0007015: Actin filament organization 5 0.0995
GO:0015629: Actin cytoskeleton 39 5.30 × 10-19
  Cellular component GO:0005856: Cytoskeleton 86 2.20 × 10-14
GO:0016459: Myosin complex 21 1.26 × 10-15
GO:0032982: Myosin filament 11 2.32 × 10-12
GO:0044430: Cytoskeletal part 51 1.16 × 10-6
GO:0005884: Actin filament 5 0.0134
Cell signalling 31 4.78 × 10-5 to 0.0899
  GO:0007154: Cell communication 32 4.78 × 10-5
GO:0007267: Cell-cell signalling 23 1.33 × 10-4
GO:0007169: Transmembrane protein tyrosine kinase signalling 17 3.85 × 10-4
GO:0007167: Enzyme linked receptor protein signalling pathway 20 0.0011
GO:0008543: Fibroblast growth factor receptor signalling pathway 5 0.0139
GO:0045168: Cell-cell signalling involved in cell fate specification 4 0.0271
GO:0040036: Regulation of fibroblast growth factor signalling 3 0.0451
GO:0043409: Negative regulation of MAPKKK cascade 3 0.0614
GO:0007219: Notch signalling pathway 5 0.0899
  1. All GO terms are associated with the subontology “Biological Process” except where indicated under Cytoskeleton, where Cellular Component was also used.
  2. 1P-value of enrichment of GO terms using DAVID analysis software; similar results were found with GOstat.
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BMC Genomics

ISSN: 1471-2164

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