Down-regulated Wnt Pathway genes | ||||||||
---|---|---|---|---|---|---|---|---|
Fold change | Gene symbol | Gene title | Role in pathway | Reference for role in pathway | ||||
RNA-seq | Microarray | Ligand | Receptor | Intra-cellular | Target | |||
  # | 41.05 | Fgf4 | Fibroblast growth factor 4 |  |  |  | T | [37] |
  # |  | Snai3 | Snail homolog 3 |  |  |  | PT | Snai1[38] |
  90.87 | 32.06 | Cacng1 | Calcium channel, voltage-dependent, gamma subunit 1 |  |  |  | T | [39] |
  42.86 | 18.77 | Pitx3 | Paired-like homeodomain transcription factor 3 |  |  |  | PT | Pitx2[40] |
  37.43 | 17.22 | Kremen2 | Kringle containing transmembrane protein 2 |  | Co-Rec |  | [41] | |
  29.52 |  | Ccnb3 | Cyclin B3 |  |  |  | PT | CyclinD1[42] |
  12.29 | 7.05 | Rxrg | Retinoid X receptor gamma |  |  |  | PT | Rarg[43] |
  5.95 | 5.20 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat 2 |  |  | PT | Islr[44] | |
  4.87 |  | Pitx2 | Paired-like homeodomain transcription factor 2 |  |  |  | T | [40] |
  3.58 |  | Fzd10 | Frizzled homolog 10 |  | R |  |  | [45] |
  3.16 | 2.21 | Dll1 | Delta-like 1 |  |  |  | T | [46] |
  3.05 |  | Prg4 | Lubricin |  |  |  | T | [30] |
  2.81 | 2.57 | Lrrn1 | Leucine rich repeat protein 1, neuronal |  |  |  | T | [47] |
  2.52 |  | Sall1 | Sal-like 1 |  |  |  | PT | Sall4:[36] |
  2.47 |  | Tnik | TRAF2 and NCK interacting kinase |  |  | TF-act | [48] | |
  2.32 |  | Tcf15 | Transcription factor 15 |  |  |  | T |  |
  2.32 |  | Met | Met proto-oncogene |  |  |  | T | [49] |
  2.18 | 2.28 | Cd44 | CD44 antigen |  |  |  | T | [50] |
  2.09 |  | Jag2 | Jagged2 |  |  |  | PT | Jag1[51] |
Up-regulated Wnt pathway genes | ||||||||
  4.36 | 4.91 | Grem2 | Gremlin |  |  |  | T | [52] |
  3.96 |  | Wnt2 | Wingless-related MMTV integration site 2 | L |  |  |  |  |
  3.50 |  | Wnt2b | Wingless-related MMTV integration site 2b | L |  |  |  |  |
  3.07 |  | Wnt16 | Wingless-related MMTV integration site 16 | L |  |  |  |  |
  2.85 | 2.90 | Kcnd2 | Potassium voltage-gated channel, shal-related family, member 2 |  | T | [47] | ||
  2.73 |  | Cldn1 | Claudin-1 |  |  |  | T | [53] |
  2.44 |  | Dkk2 | Dickkopf | Ant |  | T | ||
  2.43 | 3.08 | Rspo2 | R-spondin 2 | L |  |  | T | |
  2.37 |  | Epha4 | Eph receptor A4 |  |  |  | T | [47] |
  2.11 |  | Elavl2 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 |  | T | [47] | ||
  2.10 |  | Cpz | Carboxypeptidase Z | Co-act |  |  | [33] | |
  2.09 | 2.62 | Sfrp2 | Secreted frizzled related protein 2 | Ant |  | T | [57] | |
  2.03 |  | Wnt4 | Wingless-related MMTV integration site 4 | L |  |  |  |  |
  2.02 |  | Rspo3 | R-spondin 3 | L |  |  | T | |
 | 2.41 | E330013P04Rik | RIKEN cDNA E330013P04 gene |  |  |  | T | [47] |