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Table 5 Differentially expressed Wnt signalling pathway genes

From: Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

Down-regulated Wnt Pathway genes
Fold change Gene symbol Gene title Role in pathway Reference for role in pathway
RNA-seq Microarray Ligand Receptor Intra-cellular Target
  # 41.05 Fgf4 Fibroblast growth factor 4     T [37]
  #   Snai3 Snail homolog 3     PT Snai1[38]
  90.87 32.06 Cacng1 Calcium channel, voltage-dependent, gamma subunit 1     T [39]
  42.86 18.77 Pitx3 Paired-like homeodomain transcription factor 3     PT Pitx2[40]
  37.43 17.22 Kremen2 Kringle containing transmembrane protein 2   Co-Rec   [41]
  29.52   Ccnb3 Cyclin B3     PT CyclinD1[42]
  12.29 7.05 Rxrg Retinoid X receptor gamma     PT Rarg[43]
  5.95 5.20 Islr2 Immunoglobulin superfamily containing leucine-rich repeat 2    PT Islr[44]
  4.87   Pitx2 Paired-like homeodomain transcription factor 2     T [40]
  3.58   Fzd10 Frizzled homolog 10   R    [45]
  3.16 2.21 Dll1 Delta-like 1     T [46]
  3.05   Prg4 Lubricin     T [30]
  2.81 2.57 Lrrn1 Leucine rich repeat protein 1, neuronal     T [47]
  2.52   Sall1 Sal-like 1     PT Sall4:[36]
  2.47   Tnik TRAF2 and NCK interacting kinase    TF-act [48]
  2.32   Tcf15 Transcription factor 15     T  
  2.32   Met Met proto-oncogene     T [49]
  2.18 2.28 Cd44 CD44 antigen     T [50]
  2.09   Jag2 Jagged2     PT Jag1[51]
Up-regulated Wnt pathway genes
  4.36 4.91 Grem2 Gremlin     T [52]
  3.96   Wnt2 Wingless-related MMTV integration site 2 L     
  3.50   Wnt2b Wingless-related MMTV integration site 2b L     
  3.07   Wnt16 Wingless-related MMTV integration site 16 L     
  2.85 2.90 Kcnd2 Potassium voltage-gated channel, shal-related family, member 2   T [47]
  2.73   Cldn1 Claudin-1     T [53]
  2.44   Dkk2 Dickkopf Ant   T [47, 54]
  2.43 3.08 Rspo2 R-spondin 2 L    T [47, 55, 56]
  2.37   Epha4 Eph receptor A4     T [47]
  2.11   Elavl2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2   T [47]
  2.10   Cpz Carboxypeptidase Z Co-act    [33]
  2.09 2.62 Sfrp2 Secreted frizzled related protein 2 Ant   T [57]
  2.03   Wnt4 Wingless-related MMTV integration site 4 L     
  2.02   Rspo3 R-spondin 3 L    T [47, 58]
  2.41 E330013P04Rik RIKEN cDNA E330013P04 gene     T [47]
  1. #No numerical value for fold change as no transcripts detected in the Mutant.
  2. T -Target, PT -Potential Target, R -Receptor, Co-Rec -Co-Receptor, TF-act -Transcription Factor activator, L -Ligand, Ant -Antagonist, Co-act -Co-activator.