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Table 6 Differentially expressed genes associated with other signalling pathways

From: Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

Down-regulated   Up-regulated  
Bone morphogenetic protein signalling pathway
Fold change Gene symbol Gene title Role in pathway
  RNA-seq Microarray   Reference
  87.94 50.88 Hfe2 Hemochromatosis type 2 Co-Rec [59]
  5.25   Fgf8 Fibroblast growth factor 8 T [60]
  2.44   Scx Scleraxis T [61]
  2.17   Egr2 Early growth response 2 T [62]
  2.03   Bmp3 Bone morphogenetic protein 3 L  
Hedgehog signalling pathway
  14.55 4.59 Hhatl Hedgehog acyltransferase-like L-act [63]
  2.70   Ptchd1 Patched domain containing 1 R  
  2.27   Hhip Hedgehog interacting protein Ant, T [64]
  2.14   Ptch1 Patched 1 T [65]
Fibroblast growth factor signalling pathway
  #   Fgf4 Fibroblast growth factor 4 L  
  #   Fgf6 Fibroblast growth factor 5 L  
  5.25   Fgf8 Fibroblast growth factor 8 L  
  5.10   Fgf5 Fibroblast growth factor 5 L  
  4.54 3.23 Fgfr4 Fibroblast growth factor receptor 4 R  
  3.24   Spry1 Sprouty homolog 1 Ant [66]
  3.22   Spry4 Sprouty homolog 4 Ant  
  2.75   Spry2 Sprouty homolog 2 Ant [66]
  2.39   Fgf2 Fibroblast growth factor 2 L  
  2.134 2.48 Fgf10 Fibroblast growth factor 10 L  
Hippo signalling pathway
  98.29 49.05 Vgll2 Vestigial like 2 homolog (Drosophila) Co-TF [67]
  3.86 4.38 Tead4 TEA domain family member 4 Co-TF [68]
  2.96   Fat4 Fat tumor suppressor homolog 4 R [69]
  2.43   Fat2 Fat tumor suppressor homolog 2 R [69]
Notch signalling pathway
  5.64   Dner Delta/notch-like EGF-related receptor R [70]
  3.16 2.21 Dll1 Delta-like 1 (Drosophila) L [71]
  2.69   Hes6 Hairy and enhancer of split 6 T [72]
  2.54   Dtx4 Deltex homolog 4 T [72]
  2.09   Jag2 Jagged 2 R [71]
  3.25 2.87 Nrg1 Neuregulin 1 T [73]
  2.36 2.09 Foxc2 Forkhead box C2 Upstream-activator [74]
  2.27 2.29 Cntn1 Contactin 1 PL [75]
  1. #No numerical value for fold change as no transcripts detected in the Mutant.
  2. Co-Rec -Co-Receptor, T -Target, L -Ligand, L-act- Ligand activator, R -Receptor, Ant -Antagonist, Co-TF- -Co-Transcription Factor, PL –Potential Ligand.