Uncovering adaptive evolution in the human lineage

BMC Genomics

Table 1 Fixation index (FI) and related statistics for different human gene sets

	SNPs DAF ≥ 1%				SNPs DAF ≥ 15%				SNPs DAF ≥ 30%				SNPs DAF ≥ 60%
Data set	N	FI	DoS	α	N	FI	DoS	α	N	FI	DoS	α	N	FI	DoS	α
All genes	8019	0.73	-0.074	-0.361	5859	0.88	-0.031	-0.142	4744	0.94	-0.013	-0.059	2766	1.00	0.001	0.002
Human accelerated	182	1.60	0.116	0.375	15	1.55	0.109	0.356	136	1.69	0.131	0.409	75	1.68	0.129	0.405
Human BS test	216	1.16	0.037	0.137	172	1.27	0.058	0.209	135	1.39	0.080	0.278	78	1.66	0.123	0.398
Rapidly evolving	166	1.25	0.056	0.202	123	1.27	0.06	0.213	101	1.2	0.045	0.167	64	1.20	0.044	0.163
Mammalian-specific	77	0.71	-0.079	-0.413	57	0.95	-0.014	-0.058	47	1.04	0.010	0.042	28	0.91	-0.023	-0.100

Data are for genes with at least one polymorphic site. DoS: direction of selection; α: proportion of adaptive substitutions. SNP: single nucleotide polymorphism. DAF: derived allele frequency.

ISSN: 1471-2164