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Table 2 Genes with multiple evidence of positive selection in the human lineage

From: Uncovering adaptive evolution in the human lineage

 

Ensembl protein ID

Description

Dn

Ds

Pn

Ps

p-value MK

Divergence-based methods

TLE6

ENSP00000403096

Transducin-like enhancer of split 6

9

2

0

4

0.004

BS test

USHBP1

ENSP00000252597

Usher syndrome 1C binding protein 1

11

2

2

5

0.016

Accelerated

SYBU

ENSP00000415654

Syntabulin (syntaxin-interacting)

3

1

0

4

0.025

Accelerated

C20orf96

ENSP00000353470

Chromosome 20 ORF 96

11

2

1

3

0.04

BS test

TXLNB

ENSP00000351206

Taxilin beta

7

1

2

4

0.043

Accelerated, BS test

TLE4

ENSP00000365703

RTransducin-like enhancer of split 4

14

4

0

2

0.044

BS test

FBF1

ENSP00000401215

Fas (TNFRSF6) binding factor 1

13

1

5

4

0.044

Accelerated, BS test

  1. MK: McDonald-Kreitman test; BS test: branch-site test; accelerated: showing human-specific evolutionary rate acceleration.