Table 2 Distribution of essential features among respiratory pathogens

tRNA

4

18

0

12

8

rRNA

1

31

41

44

30

sRNA

n/a

n/a

n/a

80

9

Essential Protein-coding ORFs

445

431

532

414

325

Protein of unknown functions

159

172

225

186

127

Metabolism

173

142

182

124

100

Genetic Information Processing

93

95

101

95

93

Environmental Information Processing

20

24

24

9

5

Overrepresented/essential KEGG pathways

236

437

196

307

356

Metabolism

136

221

95

171

213

Genetic Information Processing

74

177

74

128

129

Environmental Information Processing

26

38

26

8

14

Cellular Processes

0

1

1

0

0

Overrepresented/essential SEED subsystems

449

513

602

450

355

Protein metabolism

84

85

99

100

93

Cofactors, Vitamins, Prosthetic Groups, Pigments

75

61

80

29

25

Cell Wall and Capsule

47

60

78

47

30

Amino Acids and Derivatives

41

59

58

14

11

Respiration

41

16

34

8

7

Fatty Acids, Lipids, and Isoprenoids

29

36

40

26

21

RNA Metabolism

25

59

71

60

39

Carbohydrates

24

30

46

47

35

DNA Metabolism

19

37

35

45

41

Stress Response

18

17

9

10

8

Nucleosides and Nucleotides biosynthesis

17

13

11

25

9

Virulence, Disease and Defence

16

18

18

16

15

Regulation and Cell Signalling

8

4

8

6

5

Cell Division and Cell Cycle

5

18

15

17

16