Detected putative LAP gene cluster. A Gene cluster of plantazolicin (pzn) (B. amyloliquefeaciens FZB42), streptolysin S (sag) (S. pyrogenes) and clostridiolysin S (clos) (C. botulinum ATCC 3502) in comparison to putative LAP gene clusters of B. intermedia, B. hyodysenteriae and T. mathranii mathranii A3; Numbers represent the locus tag for each gene within the genome sequence of each organism. B Comparison of precursor peptides of plantazolicin (PlnA), streptolysin S (SagA), clostridiolysin S (ClosA) with putative precursor peptides of B. intermedia, B. hyodysenteriae, and T. mathranii mathranii A3; Cleavage site of leader and core peptide in bold. C Introduction of heterocycles in plantazolicin by cyclodehydrogenase (PznC) and dehydrogenase (PznB) enzyme complex, X = S,O. D Chemical structure of plantazolicin.