Figure 1

Multiple alignment of CYTH domains Proteins are represented by their corresponding gene names, followed by a species abbreviation, followed by the Genbank gi number. The coloring reflects the amino acid conservation at 90% consensus. The consensus abbreviations and coloring scheme are as follows: h: hydrophobic residues (L,I,Y,F,M,W,A,C,V), l: aliphatic (L,I,A,V) and a: aromatic (F,Y,W,H) residues shaded yellow, c: charged (K,E,R,D,H) residues, and p: polar (S,T,E,C,D,R,K,H,N,Q) residues colored purple; +: basic (K,R,H) residues shaded blue, -: acidic (D,E) residues shaded red, s: small (S,A,C,G,D,N,P,V,T) and u:tiny (G,A,S) residues, colored green; b: big (L,I,F,M,W,Y,E,R,K,Q) residues shaded gray. Secondary structure assignments: H: Helix, E: Extended (Strand).