Figure 8

Schematic diagram of the domain structures of human pARTs and pARTs from distantly related organisms. Recognizable protein domains in the pART family are represented by the icons defined on the right. The domain structures of human pARTs (on the left, numbered Pacman icons) and related pARTs from other species are illustrated schematically. Potential DNA binding domains are boxed in red, potential ubiquitylation motifs are boxed in green. Members of the five pART family subgroups are grouped within colored boxes using the color-coding as in Figure 2: subgroup 1 = red, 2 = pink, 3 = orange, 4 = green, 5 = grey. Amino acids corresponding to the HYE catalytic site motif of DT and PARP-1 are shown in the mouths of the Pacman icons. Black numbers indicate protein lengths in number of amino acids. Species of origin is color-coded in the two letter abbreviation of the organisms as in Figures 4 and 9: Drosophila melanogaster (Dm) and Anopheles gambiae (Ag) purple, Caenorrhabditis elegans (Ce), Dictyostelium discoideum (Dd), Entamaoeba histolytica (Eh), and Gibberella zeae (Gz) blue, Arabidopsis thaliana (At) green, Chilo iridescent virus (Ci) and Bacteriophage Aeh (Ba) brown. Protein database accession numbers for the illustrated pARTs are listed in Figures 4 and 9. On the right, the approximate size of each domain is indicated in number of amino acid residues. The accession numbers of the respective domain families in the pfam, cd, and smart databases are indicated. In case of zinc finger (zf) containing domains, the number of recognizable zinc fingers is indicated by colored bars within the icon.