Figure 1

Hierarchical clustering of 920 Saccharomyces cerevisiae genes with a significant transcriptional response to MMS and/or γ-ray. S. cerevisiae cultures were exposed to one of three doses of MMS (0,001%, 0.01%, or 0.1% (v/v)) or one of three doses of γ-ray (1 Gy, 10 Gy, or 100 Gy) and their global transcriptional response was compared to that of control cells not exposed to DNA damaging agents. All genes clustered had at least a 3-fold change in expression level to one or more experimental conditions and a FDR value < 0.05 for at least one condition. Clustering of the experiments led to the most similar exposure conditions being grouped together. Four clusters are highlighted: (A) genes repressed by MMS and γ-ray, (B) genes repressed by MMS and induced by γ-ray, (C) genes induced by MMS and repressed by γ-ray, and (D) genes induced by both MMS and γ-ray.