Table 1 Peptidases of Entamoeba histolytica

1

EhCP-A1

CA, C1, A

XP_650156

XM_645064

315

Q₁₁₂C₁₁₈H₂₅₉N₂₇₉

SP: 13, Pro: 80, TM: -

cysteine protease 1

2

EhCP-A2

CA, C1, A

XP_650642

XM_645550

315

Q₁₁₂C₁₁₈H₂₅₉N₂₇₉

SP: 13, Pro; 80, TM: -

cysteine proteinase 2

3

EhCP-A3

CA, C1, A

XP_653254

XM_648162

308

Q₁₁₁C₁₁₅H₂₅₁N₂₇₁

SP: 13, Pro: 79, TM: -

cysteine proteinase acp1

4

EhCP-A4

CA, C1, A

XP_656602

XM_651510

311

Q₁₁₂C₁₁₈H₂₅₃N₂₇₃

SP: 20, Pro: 73, TM: -

cysteine proteinase

5

EhCP-A5

CA, C1, A

XP_650937

XM_645845

318

Q₁₁₃C₁₁₉H₂₆₁N₂₇₁

SP: 20, Pro: 72, TM: -

cysteine proteinase

6

EhCP-A6

CA, C1, A

XP_657364

XM_652272

320

Q₁₁₅C₁₂₂H₂₆₁N₂₈₁

SP: 17, Pro: 79, TM: -

cysteine proteinase

7

EhCP-A7

CA, C1, A

XP_648996

XM_643904

315

Q₁₁₂C₁₁₈H₂₅₉N₂₇₉

SP: 13, Pro: 80, TM: -

cysteine protease 8

8

EhCP-A8

CA, C1, A

XP_657446

XM_652354

317

Q₁₁₆C₁₂₂H₂₆₀N₂₈₀

SP: 15, Pro: 82, TM: -

cysteine protease 9

9

EhCP-A9

CA, C1, A

XP_655675

XM_650583

297

Q₁₂₆C₁₃₂H₂₆₉N₂₉₀

SP: 17, Pro: 90, TM: -

cysteine protease 10

10

EhCP-A10

CA, C1, A

XP_651147

XM_646598

420

Q₁₈₅C₁₉₁H₃₃₆N₃₅₇

SP: 18, Pro: 148, TM: -

cysteine protease 17

11

EhCP-A11

CA, C1, A

XP_651690

XM_646598

324

Q₁₁₈C₁₂₄H_-N₂₈₇

SP: 17, Pro: 79, TM: -

cysteine protease 19

12

EhCP-A12

CA, C1, A

XP_653823

XM_648731

317

not identified, N₂₈₁

SP: 14, Pro: 83, TM: -

cysteine proteinase

13

EhCP-A13

CA, C1, A

not annotated

250 (IS)

Q₁₂₅C₁₃₀

SP: 18, Pro: 108

14

EhCP-B1

CA, C1, A

XP_651581

XM_646489

426

Q₁₀₅C₁₀₁H₃₀₈N₃₂₈

SP: 15, Pro: 106, hydroph. C-term.

cysteine proteinase 7

15

EhCP-B2

CA, C1, A

AAO03568

431

Q₁₄₅C₁₅₁H₃₀₈S₃₂₈

SP: 15, Pro: 106, GPI

cysteine protease 11

16

EhCP-B3

CA, C1, A

XP_656747

XM_651655

474

Q₁₅₅C₁₆₁H₃₀₄N₃₂₄

SP: 16, Pro: 107, TM: 444–466

cysteine protease 12-related

17

EhCP-B4

CA, C1, A

XP_648501

XM_643409

379

Q₁₅₃C₁₅₉H₃₀₂N₃₂₂

SP: 16, Pro: 105, TM: 355–377 or GPI

cysteine protease 13

18

EhCP-B5

CA, C1, A

XP_652671

XM_647579

434

Q₁₅₁C₁₅₇H₃₁₁N₃₂₆

SP: 12, Pro: 108, GPI

cysteine protease 14-related

19

EhCP-B6

CA, C1, A

XP_652465

XM_647373

300

Q₈₄C₉₀H₂₃₂N₂₅₂

SP: 14, Pro: 55, hydroph. C-term.

cysteine protease 15

20

EhCP-B7

CA, C1, A

XP_650400

XM_645308

650

Q-C₁₇₁H₃₁₂N₃₃₂

SP: 18, Pro: 144, hydroph. C-term.

cysteine protease 16

21

EhCP-B8

CA, C1, A

XP_651049

XM_645957

473

Q₁₁₀C₁₅₆H₃₂₉N₂₄₉

SP: 15, Pro: 105, GPI

cysteine protease 18

22

EhCP-B9

CA, C1, A

XP_652993

XM_647901

446

Q₁₆₁C₁₆₇H₃₂₈N₃₄₈

SP: 19, Pro: 112, hydroph. C-term

cysteine protease

23

EhCP-B10

CA, C1, A

XP_648306

XM_643214

372 (IS)

Q₆₇C₇₆H₂₄₄N₂₆₄

hydroph. C-term.

cysteine protease

24

EhCP-B11

CA, C1, A

XP_648013

XM_642921

133 (IS)

cysteine protease 11-related

25

EhCP-C1

CA, C1, A

XP_654453

XM_649361

586

Q₇₀C₇₆H-N₃₄₅

SA: 12–34

hypothetical protein

26

EhCP-C2

CA, C1, A

XP_656632

XM_651540

567

Q₈₇C₉₃H₃₀₆N₃₂₆

SA: 27–49

hypothetical protein

27

EhCP-C3

CA, C1, A

XP_655128

XM_650036

572

Q₉₄C₁₀₀H₃₂₂N₃₃₇

SA: 17–39

hypothetical protein

28

EhCP-C4

CA, C1, A

XP_655800 XM_650708

502

Q₃₂C₃₈H₂₄₆N₂₇₁

SP: 15

hypothetical protein

29

EhCP-C5

CA, C1, A

XP_654800 XM_649708

557

Q₉₀C₉₆H₃₀₂N₃₂₇

SA: 20–42

hypothetical protein

30

EhCP-C6

CA, C1, A

XP_651553 XM_646461

557

Q₉₃C₉₉H₂₉₃N-

SA: 14–36

hypothetical protein

31

EhCP-C7

CA, C1, A

XP_657273 XM_652181

595

Q₈₉C₉₅H₂₉₇N₃₂₂

SA: 19–41

hypothetical protein

32

EhCP-C8

CA, C1, A

XP_655479 XM_652181

627

Q₉₁C₉₆H₃₁₇N₃₆₆

SA: 29–51

hypothetical protein

33

EhCP-C9

CA, C1, A

XP_655011 XM_649919

518

not identified

SA: 12–34

hypothetical protein

34

EhCP-C10

CA, C1, A

XP_654829 XM_649737

530

Q₈₇C₉₃H₂₉₉N₃₂₄

SA: 15–37

hypothetical protein

35

EhCP-C11

CA, C1, A

XP_648083 XM_642991

526

not identified

SA: 20–42

hypothetical protein

36

EhCP-C12

CA, C1, A

XP_650829 XM_645737

473

not identified

SA: 26–48, TM: 449–471

hypothetical protein

37

EhCP-C13

CA, C1, A

XP_656556 XM_651464

564

Q₈₉C₉₅H₂₆₆N₂₉₀

SA: 21–43

hypothetical protein

38

EhCALP1

CA, C2

XP_649922 XM_644830

591

not identified

SP: -, TM: -

calpain-like cysteine protease

39

EhCALP2

CA, C2

XP_657312 XM_652220

473

Q₅₁C₅₇H₂₀₆N₂₂₇

SP: -, TM: -

calpain family cysteine protease

40

EhUBHY

CA, C19

XP_657356 XM_652264

444

not identified

SP: -, TM: -

peptidase

41

EhUBP

CA, C19

XP_654028 XM_648936

352

N₃₀C₃₅H₃₃₀D₃₄₈

SP: -, TM: -

ubiquitin-specific protease

42

EhUCH

CA, C19

XP_655880 XM_650788

386

N₃₇C₄₂H₃₄₅D₃₆₀

SP: -, TM: -

ubiquitin carboxyl-terminal hydrolase

43

EhUlp1-1

CA, C48

XP_650529 XM_645437

197

H₉₅D₁₁₂Q₁₄₆C₁₅₂

SP: -, TM: -

Ulp1 protease

44

EhUlp1-2

CA, C48

XP_651052 XM_645960

538

H₃₉₉D₄₃₅Q₄₈₂C₄₈₈

SP: -, TM: -

Ulp1 protease

45

EhUlp1-3

CA, C48

XP_657158 XM_652066

285

H₁₇₄D₁₉₁Q₂₃₄C₂₄₀

SP: -, TM: -

Ulp1 protease

46

EhAUTO1

CA, C54

XP_651386 XM_646294

325

Y₇₁C₁₀₀D₂₅₁H₂₅₃

SP: -, TM: -

peptidase

47

EhAUTO2

CA, C54

XP_653798 XM_648706

364

Y₉₃C₁₀₃D₂₇₈H₂₈₀

SP: -, TM: -

peptidase

48

EhAUTO3

CA, C54

XP_652043 XM_646951

364

Y₉₂C₁₀₃D₂₇₉H₂₈₁

SP: -, TM: -

hypothetical protein

49

EhAUTO4

CA, C54

XP_656724 XM_651632

348

Y₉₂C₁₁₂D₂₆₅H₂₆₇

SP: -, TM: -

hypothetical protein

50

EhOTU

CA, C65

XP_654013 XM_648921

259

D₁₀₅C₁₀₈H₂₁₂

SP: -, TM: -

OTU-like cysteine protease

Aspartic peptidase

51

EhAsP22-1

AD, A22, A

XP_654079 XM_648987

340

D₁₇₈D₂₂₃

SP:24 or TM: 7–26 + 7 × TM

Intramembrane protease

52

EhAsP22-2

AD, A22, A

XP_652820 XM_647728

316

D₁₅₇, D₂₀₉

SP: 19 or TM: 2–19 + 8 × TM

Signal peptide peptidase

53

EhAsP22-3

AD, A22, A

XP_657563 XM_652471

320

D₁₅₇D₂₀₅

SA:7–29 + 8 xTM

Signal peptide peptidase

54

EhAsP22-4

AD, A22, A

XP_653696 XM_648604

396

D₂₄₅D₃₁₈

SP: -, 7 × TM

Presenilin 1-related peptidase

Serine peptidase

55

EhSP9-1

SC, S9, C

XP_655265 XM_650173

653

S₅₁₄D₅₉₅H₆₂₇

SP: 15, TM: -

dipeptidyl-peptidase

56

EhSP9-2

SC, S9, C

XP_655222 XM_650130

665

S₅₂₆D₆₀₇H₆₃₉

SP: 15, TM: -

dipeptidyl-peptidase

57

EhSP9-3

SC, S9, C

XP_656380 XM_651288

656

S₅₁₆D₅₉₉H₆₃₂

SP: -, TM: -

prolyl oligopeptidase

58

EhSP9-4

SC, S9, C

XP_649111 XM_644019 XP_648413 XM_643321 XP_655473 XM_650381

669

not identified

SP: 16, TM: -

dipeptidyl-peptidase

59

EhSP9-5

SC, S9

XP_655676 XM_650584

102 (IS)

SP: -, TM: -

prolyl oligopeptidase family

60

EhSP26-1

SF, S26, B

XP_653142 XM_648050

189

S₆₅H₁₀₆

SP: -, TM: 34–56, 163–185

signal peptidase (signalase)

61

EhSP26-2

SF, S26

XP_651791 XM_646699

121

not identified

SP: -, TM: -

microsomal signal peptidase

62

EhSP28-1

SC, S28

XP_656762 XM_651670

457

S₁₆₅D₃₉₅H₄₂₁

SP: 15, TM: -

serine peptidase

63

EhSP28-2

SC, S28

XP_648991 XM_643899

480

S₁₆₅D₄₁₈H₄₄₄

SP: 15, TM: -

serine peptidase

64

EhSP28-3

SC, S28

XP_652089 XM_646997

466

S₁₅₅D₄₀₄H₄₃₁

SP: -, TM: -

serine peptidase

Metallo peptidases

65

EhMP1-1

MA, M1

XP_652558 XM_647466

827

H₂₉₅E₂₉₆H₂₉₉E₃₁₈Y₄₈₁

SP: -, TM: -

aminopeptidase

66

EhMP3-1

MA, M3

XP_649877 XM_644785

675

H₄₆₃E₄₆₄H₄₆₇E₄₉₃

SP: -, TM: -

oligopeptidase A

67

EhMP3-2

MA, M3

XP_649600 XM_644508

710

H₄₉₈E4₉₉H₅₀₂E₅₂₇

SP: -, TM: -

oligopeptidase A

68

EhMP8-1

MA, M8

XP_655394 XM_650302

643

H₂₀₆E₂₀₇H₂₁₀H₂₇₀M₂₈₁

SP: 18, TM: 605–627

leishmaniolysin-related peptidase

69

EhMP8-2

MA, M8

XP_652632 XM_647540

662

H₂₀₇E₂₀₈H₂₁₁H₂₆₇M₂₇₈

SP: -, TM: 598–620

leishmaniolysin-related peptidase

70

EhMP48-1

MA, M48, A

XP_648770 XM_643678

416

H₂₇₄E₂₇₅H₂₇₈E₃₅₃

SA: 4–21 + 6 × TM

CAAX prenyl protease

71

EhMP16-1

ME, M16, C

XP_654849 XM_649757

970

H₅₉E₆₂H₆₃E₁₃₇E₁₅₈

SP: -, TM: -

Zn-dependent peptidase, eupitrilysin

72

EhMP24-1

MG, M24, A

XP_651539 XM_646447

409

H₁₆₅D₁₈₆D₁₉₇H₂₆₆E₂₉₉E₃₉₄

SP: -, TM: -

methionine aminopeptidase

73

EhMP24-2

MG, M24, B

XP_657085 XM_651993

471

H₂₄₄D₂₆₅D₂₇₆H₃₅₄H₃₅₈H₃₆₅E₄₀₁E₄₄₁

SP: -, TM: -

Xaa-Pro dipeptidase

74

EhMP24-3

MG, M24, B

XP_654211 XM_649119

563

H₃₆₄D₃₈₄D₃₉₆H₄₆₁H₄₆₅H₄₇₀E₄₉₁E₅₀₅

SP: -, TM: -

aminopeptidase

75

EhMP24-4

MG, M24, B

XP_650646 XM_645554

559

H₃₄₆D₃₆₆D₃₇₈H₄₄₃H₄₄₇H₄₅₂E₄₇₃E₄₈₇

SP: -, TM: -

aminopeptidase

76

EhMP24-5

MG, M24, B

XP_649980 XM_644888

589

H₃₆₉D₃₈₉D₄₀₁H₄₆₆H₄₇₅E₄₉₆E₅₁₀

SP: -, TM: -

aminopeptidase

77

EhMP24-6

MG, M24, B

XP_653331 XM_648239 XM_649891 XM_644799

371

not identified

SP: -, TM: -

peptidase

78

EhMP18-1

MH, M18

XP_656618 XM_651526

435

H₇₉D₈₁D₂₂₂E₂₅₈E₂₅₉D₃₀₇H₄₀₂

SP: -, TM: -

aminopeptidase

79

EhMP18-2

MH, M18

XP_650466 XM_645374

431

H₈₁D₈₂D₂₂₈E₂₆₂E₂₆₃D₃₁₁H₄₀₁

SP: -, TM: -

aspartyl aminopeptidase

80

EhMP20-1

MH, M20, B

XP_656428 XM_651336

379

H₇₅D₁₃₃E₁₆₃E₁₆₄D₁₈₆H₃₅₃

SP: -, TM: -

peptidase T

81

EhMP20-2

MH, M20, B

XP_650152 XM_645060

401

H₇₉D₁₃₉E₁₇₂E₁₇₃D₁₉₅H₃₇₆

SP: -, TM: -

peptidase T

82

EhMP20-3

MH, M20, C

XP_656545 XM_651453 XP_655596 XM_650504 XP_652163 XM_647071

516

H₉₅D₉₇D₁₃₄E₁₆₅E₁₆₆D₁₉₂H₄₉₀

SP: -, TM: -

aminoacyl-histidine dipeptidase

83

EhMP20-4

MH, M20, C

XP_655616 XM_650524

505

H₉₅D₉₇D_-E₁₅₄E₁₅₅D₁₈₁H₄₇₇

SP: -, TM: -

aminoacyl-histidine dipeptidase

84

EhMP22-1

MK, M22

XP_652292 XM_647200

335

unknown

SP: -, TM: -

glycoprotein endopeptidase

85

EhMP49-1

M, M49

XP_654273 XM_649181

645

H₄₁₂E₄₁₃H₄₁₇E₄₆₇

SP: -, TM: -

dipeptidyl-peptidase III

86

EhU48-1

U, U48

XP_656466 XM_651374

216

H₂₇₄E₂₇₅H₂₇₈E₃₅₃

SA: 4–26 + 6 × TM

CAAX prenyl protease