Gadasi H, Kessler E: Correlation of virulence and collagenolytic activity in Entamoeba histolytica. Infect Immun. 1983, 39: 528-531.
CAS
PubMed Central
PubMed
Google Scholar
Lushbaugh WB, Hofbauer AF, Pittman FE: Entamoeba histolytica: purification of cathepsin B. Exp Parasitol. 1985, 59: 328-336. 10.1016/0014-4894(85)90088-8.
Article
CAS
PubMed
Google Scholar
Luaces AL, Barrett AJ: Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica. Biochem J. 1988, 250: 903-909.
Article
CAS
PubMed Central
PubMed
Google Scholar
Reed SL, Keene WE, McKerrow JH: Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol. 1989, 27: 2772-2777.
CAS
PubMed Central
PubMed
Google Scholar
Schulte W, Scholze H: Action of the major protease from Entamoeba histolytica on proteins of the extracellular matrix. J Protozool. 1989, 36: 538-543.
Article
CAS
PubMed
Google Scholar
Keene WE, Hidalgo ME, Orozco E, McKerrow JH: Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase. Exp Parasitol. 1990, 71: 199-206. 10.1016/0014-4894(90)90022-5.
Article
CAS
PubMed
Google Scholar
Li E, Yang WG, Zhang T, Stanley SL: Interaction of laminin with Entamoeba histolytica cysteine proteinases and its effect on amebic pathogenesis. Infect Immun. 1995, 63: 4150-4153.
CAS
PubMed Central
PubMed
Google Scholar
Stanley SL, Zhang T, Rubin D, Li E: Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice. Infect Immun. 1995, 63: 1587-1590.
CAS
PubMed Central
PubMed
Google Scholar
Ankri S, Stolarsky T, Bracha R, Padilla-Vaca F, Mirelman D: Antisense inhibition of expression of cysteine proteinases affects Entamoeba histolytica-induced formation of liver abscess in hamsters. Infect Immun. 1999, 67: 421-422.
CAS
PubMed Central
PubMed
Google Scholar
Tillack M, Nowak N, Lotter H, Bracha R, Mirelman D, Tannich E, Bruchhaus I: Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica. Mol Biochem Parasitol. 2006, 149: 58-64. 10.1016/j.molbiopara.2006.04.009.
Article
CAS
PubMed
Google Scholar
Zhang Z, Wang L, Seydel KB, Li E, Ankri S, Mirelman D, Stanley SL: Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis. Mol Microbiol. 2000, 37: 542-548. 10.1046/j.1365-2958.2000.02037.x.
Article
CAS
PubMed
Google Scholar
Clark GC, Alsmark UCM, Hofer M, Saito-Makano Y, Aloi V, Marion S, Weber C, Mukherjee C, Bruchhaus I, Tannich E, Leippe M, Sicheritz-Ponten T, Foster PG, Samuelson J, Noel CJ, Hirt RP, Embley TM, Gilchrist CA, Mann BJ, Singh U, Ackers JP, Bhattacharya S, Bhattacharya A, Lohia A, Guillen N, Duchene M, Nozaki T, Hall N: Stucture and content of the Entamoeba histolytica genome. Advances in Parasitology. 2007,
Google Scholar
Bruchhaus I, Loftus BJ, Hall N, Tannich E: The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation. Eukaryot Cell. 2003, 2: 501-509. 10.1128/EC.2.3.501-509.2003.
Article
CAS
PubMed Central
PubMed
Google Scholar
Goll DE, Thompson VF, Li H, Wei W, Cong J: The calpain system. Physiol Rev. 2003, 83: 731-801.
Article
CAS
PubMed
Google Scholar
Kirisako T, Ichimura Y, Okada H, Kabeya Y, Mizushima N, Yoshimori T, Ohsumi M, Takao T, Noda T, Ohsumi Y: The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol. 2000, 151: 263-276. 10.1083/jcb.151.2.263.
Article
CAS
PubMed Central
PubMed
Google Scholar
Marino G, Uria JA, Puente XS, Quesada V, Bordallo J, Lopez-Otin C: Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem. 2003, 278: 3671-3678. 10.1074/jbc.M208247200.
Article
CAS
PubMed
Google Scholar
Levine B, Yuan J: Autophagy in cell death: an innocent convict?. J Clin Invest. 2005, 115: 2679-2688. 10.1172/JCI26390.
Article
CAS
PubMed Central
PubMed
Google Scholar
Smith M, Bhaskar V, Fernandez J, Courey AJ: Drosophila Ulp1, a nuclear pore-associated SUMO protease, prevents accumulation of cytoplasmic SUMO conjugates. J Biol Chem. 2004, 279: 43805-43814. 10.1074/jbc.M404942200.
Article
CAS
PubMed
Google Scholar
Munoz ML, Calderon J, Rojkind M: The collagenase of Entamoeba histolytica. J Exp Med. 1982, 155: 42-51. 10.1084/jem.155.1.42.
Article
CAS
PubMed
Google Scholar
Scholze H, Frey S, Cejka Z, Bakker-Grunwald T: Evidence for the existence of both proteasomes and a novel high molecular weight peptidase in Entamoeba histolytica. J Biol Chem. 1996, 271: 6212-6216. 10.1074/jbc.271.11.6212.
Article
CAS
PubMed
Google Scholar
Padilla-Vaca F, Martinez-Gallardo N, Blanco-Labra A, Shmuely H, Mirelman D: Novel thermo-stable serine-metallo proteinase of Entamoeba histolytica. Arch Med Res. 2000, 31: S221-223. 10.1016/S0188-4409(00)00232-0.
Article
CAS
PubMed
Google Scholar
Flockenhaus B, Pietersma M, Bakker-Grunwald T, Scholze H: The occurrence of a tripeptidyl peptidase I in trophozoites of Entamoeba histolytica. Arch Med Res. 2000, 31: S67-68. 10.1016/S0188-4409(00)00138-7.
Article
CAS
PubMed
Google Scholar
Barrios-Ceballos MP, Martinez-Gallardo NA, Anaya-Velazquez F, Mirelman D, Padilla-Vaca F: A novel protease from Entamoeba histolytica homologous to members of the family S28 of serine proteases. Exp Parasitol. 2005, 110: 270-275. 10.1016/j.exppara.2005.02.022.
Article
CAS
PubMed
Google Scholar
Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B: Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science. 2002, 296: 2215-2218. 10.1126/science.1070925.
Article
CAS
PubMed
Google Scholar
Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE: Identification of a novel family of presenilin homologues. Hum Mol Genet. 2002, 11: 1037-1044. 10.1093/hmg/11.9.1037.
Article
CAS
PubMed
Google Scholar
Jiang P, Mellors A: O-Sialoglycoprotein endopeptidase. Handbook of Proteolytic Enzymes. Edited by: Barrett AJ, Rawlings ND, Woessner JF. 2004, Elsevier, London, 977-980. 2
Chapter
Google Scholar
Chen JM, Barrett AJ: Dipeptidyl-peptidase III. Handbook of Proteolytic Enzymes. Edited by: Barrett AJ, Rawlings ND, Woessner JF. 2004, Elsevier, London, 809-812. 2
Chapter
Google Scholar
Dolence JM, Steward LE, Dolence EK, Wong DH, Poulter CD: Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rce1p. Biochemistry. 2000, 39: 4096-4104. 10.1021/bi9923611.
Article
CAS
PubMed
Google Scholar
Trueblood CE, Boyartchuk VL, Picologlou EA, Rozema D, Poulter CD, Rine J: The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities. Mol Cell Biol. 2000, 20: 4381-92. 10.1128/MCB.20.12.4381-4392.2000.
Article
CAS
PubMed Central
PubMed
Google Scholar
MacFarlane RC, Shah PH, Singh U: Transcriptional profiling of Entamoeba histolytica trophozoites. Int J Parasitol. 2005, 35: 533-542. 10.1016/j.ijpara.2005.02.006.
Article
CAS
PubMed
Google Scholar
Weber C, Guigon G, Bouchier C, Frangeul L, Moreira S, Sismeiro O, Gouyette C, Mirelman D, Coppee JY, Guillen N: Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica. Eukaryot Cell. 2006, 5: 871-875. 10.1128/EC.5.5.871-875.2006.
Article
CAS
PubMed Central
PubMed
Google Scholar
Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B: Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. J Biol Chem. 2004, 279: 50790-5078. 10.1074/jbc.M407898200.
Article
CAS
PubMed
Google Scholar
Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL: Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Mol Cell. 1997, 1: 47-57. 10.1016/S1097-2765(00)80006-4.
Article
CAS
PubMed
Google Scholar
Urban S, Lee JR, Freeman M: Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell. 2001, 107: 173-182. 10.1016/S0092-8674(01)00525-6.
Article
CAS
PubMed
Google Scholar
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ: Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999, 398: 513-517. 10.1038/19077.
Article
CAS
PubMed
Google Scholar
Vetrivel KS, Zhang YW, Xu H, Thinakaran G: Pathological and physiological functions of presenilins. Mol Neurodegener. 2006, 1: 4-10.1186/1750-1326-1-4.
Article
PubMed Central
PubMed
Google Scholar
Smialowska A, Baumeister R: Presenilin function in Caenorhabditis elegans. Neurodegener Dis. 2006, 3: 227-232. 10.1159/000095260.
Article
CAS
PubMed
Google Scholar
Mahoney MB, Parks AL, Ruddy DA, Tiong SY, Esengil H, Phan AC, Philandrinos P, Winter CG, Chatterjee R, Huppert K, Fisher WW, L'Archeveque L, Mapa FA, Woo W, Ellis MC, Curtis D: Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Genetics. 2006, 172: 2309-2324. 10.1534/genetics.104.035170.
Article
CAS
PubMed Central
PubMed
Google Scholar
Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS: Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry. 2006, 45: 8649-8656. 10.1021/bi060597g.
Article
CAS
PubMed
Google Scholar
Carlos JL, Paetzel M, Brubaker G, Karla A, Ashwell CM, Lively MO, Cao G, Bullinger P, Dalbey RE: The role of the membrane-spanning domain of type I signal peptidases in substrate cleavage site selection. J Biol Chem. 2000, 275: 38813-3822. 10.1074/jbc.M007093200.
Article
CAS
PubMed
Google Scholar
Riahi Y, Ankri S: Involvement of serine proteinases during encystation of Entamoeba invadens. Arch Med Res. 2000, 31: S187-189. 10.1016/S0188-4409(00)00220-4.
Article
CAS
PubMed
Google Scholar
Yao C, Donelson JE, Wilson ME: The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function. Mol Biochem Parasitol. 2003, 132: 1-16. 10.1016/S0166-6851(03)00211-1.
Article
CAS
PubMed
Google Scholar
Ehrenkaufer GM, Haque R, Hackney JA, Eichinger DJ, Singh U: Identification of developmentally regulated genes in Entamoeba histolytica: insights into mechnaisms of stage conversion in a protozoan parasite. Cell Microbiol. 2007,
Google Scholar
Touz MC, Nores MJ, Slavin I, Carmona C, Conrad JT, Mowatt MR, Nash TE, Coronel CE, Lujan HD: The activity of a developmentally regulated cysteine proteinase is required for cyst wall formation in the primitive eukaryote Giardia lamblia. J Biol Chem. 2002, 277: 8474-8481. 10.1074/jbc.M110250200.
Article
CAS
PubMed
Google Scholar
Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL: A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2006, 115: 192-199. 10.1016/j.exppara.2006.08.004.
Article
PubMed
Google Scholar
Gilchrist CA, Houpt E, Trapaidze N, Fei Z, Crasta O, Asgharpour A, Evans C, Martino-Catt S, Baba DJ, Stroup S, Hamano S, Ehrenkaufer G, Okada M, Singh U, Nozaki T, Mann BJ, Petri WA: Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome. Mol Biochem Parasitol. 2006, 147: 163-176. 10.1016/j.molbiopara.2006.02.007.
Article
CAS
PubMed
Google Scholar
Ali IK, Zaki M, Clark CG: Use of PCR amplification of tRNA gene-linked short tandem repeats for genotyping Entamoeba histolytica. J Clin Microbiol. 2005, 43: 5843-5847.
Google Scholar
Diamond LS, Harlow DR, Cunnick CC: A new medium for axenic cultivation of Entamoeba histolytica and other Entamoeba. Trans R Soc Trop Med Hyg. 1978, 72: 431-432. 10.1016/0035-9203(78)90144-X.
Article
CAS
PubMed
Google Scholar
Blast. [http://www.ncbi.nlm.nih.gov/BLAST/]
Welcome Trust Sanger Institute, Entamoeba Whole Genome Shotgun. [http://www.sanger.ac.uk/Projects/E_histolytica/]
Entamoeba histolytica GeneDB. [http://www.genedb.org/genedb/ehistolytica]
TIGR Database, Entamoeba histolytica Genome Project. [http://www.tigr.org/tdb/e2k1/eha1/]
MEROPS, the peptide database. [http://merops.sanger.ac.uk/]
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methods. 2001, 25: 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar