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Table 2 Top 40 known genes altered by MS-275 in MC3T3-E1 cells

From: Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors

Gene Fold Change Welch Test
Induced   
   AMP deaminase 3 4.177 1.93E-06
   Musculoskeletal, embryonic nuclear protein 1 3.427 1.35E-05
   Adenylosuccinate synthetase like 1 3.038 4.20E-05
   Amphiregulin 2.710 4.64E-05
   Lysyl oxidase 2.697 1.92E-06
   Colony stimulating factor 1 (macrophage) 2.694 9.32E-05
   Fatty acid binding protein 4, adipocyte 2.518 4.52E-05
   Chemokine (C-C motif) ligand 9 2.505 4.00E-05
   Solute carrier family 9 isoform 3 regulator 1 2.477 3.63E-06
   Sorbitol dehydrogenase 1 2.431 1.89E-07
   Troponin C, cardiac/slow skeletal 2.408 6.23E-05
   Proline arginine-rich end leucine-rich repeat 2.391 2.05E-05
   Glutaminyl-peptide cyclotransferase (glutaminyl cyclase) 2.387 7.24E-05
   Inhibitor of DNA binding 1 2.358 1.24E-05
   Solute carrier family 40, member 1 2.275 1.04E-04
   Glutathione S-transferase, alpha 4 2.268 3.40E-07
   Septin 4 2.195 9.94E-05
   Voltage-dependent calcium channel gamma subunit-like 2.187 4.78E-05
   Immediate early response 3 2.171 4.22E-06
   Dimethylarginine dimethylaminohydrolase 1 2.165 1.49E-06
   Similar to Normal mucosa of esophagus specific gene 1 2.157 2.91E-06
   MAS-related GPR, member F 2.122 1.15E-04
   Microtubule-associated protein tau 2.101 9.32E-06
   Retinoic acid induced 3 2.095 1.92E-05
   High mobility group AT-hook 1 2.088 7.18E-05
   A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 5 2.088 7.60E-05
   Connective tissue growth factor 2.075 3.62E-05
   A kinase (PRKA) anchor protein (gravin) 12 2.036 1.78E-05
   Aldehyde dehydrogenase family 3, subfamily A1 2.029 1.25E-04
   Galactokinase 2 2.017 2.88E-06
   Dystrophia myotonica kinase, B15 2.014 3.81E-05
   Thrombospondin 1 2.005 7.11E-05
Suppressed   
   Proline 4-hydroxylase, alpha polypeptide III -2.006 4.79E-06
   Interleukin 1 receptor-like 1 -2.035 4.28E-06
   Proteasome (prosome, macropain) subunit, beta type 10 -2.063 2.96E-06
   Guanylate nucleotide binding protein 2 -2.284 2.04E-06
   Transcription factor AP-2 beta -2.299 2.27E-05
   Sirtuin 1 -2.450 6.21E-05
   Adaptor-related protein complex AP-4, sigma 1 -2.484 1.97E-06
  1. All genes were present at a FDR of 0.01 (99% confidence) relative to the vehicle control, DMSO. The list excludes ESTs and other non-annotated sequences.