MR-GSE test. Representation of the p-values (corrected for multiple testing) resulting from the MR-GSE test for each dataset and 10 gene sets specified in Additional File 1 (Table S4). In brief they are gene sets Mekagaryocyte differentiation, Identification of genes involved in the differentiation of megakaryocytes. DEGs between stem cells and differentiated megakaryocytes; Platelets, Transcription profiling of human blood platelet; ; Normal megakaryocytes, Genes highly expressed in megakaryocytes; ET megakaryocytes, Genes highly expressed in essential thrombocytopenia megakaryocytes; Cytokinesis proteome, Identification of proteins present in the midbody during cytokinesis; Spindle checkpoint, Review ; DNA repair, Review; Lymphoblast irradiation; high dose, Effect of ionising radiation on lymphoblasts; Lymphoblast irradiation; low dose, Effect of ionising radiation on lymphoblasts; Genes DE in cancer, Meta-analysis of cancer microarray data to identify genes consistently DE in tumours. This represents whether the genes present in the published gene sets are also differentially expressed in our expression profiles. For example, the genes expressed in normal or diseased megakaryocytes (lines 3 and 4) are significantly represented in the differentially expressed genes identified in the FPD and CBF approaches.