Kamachi Y, Ogawa E, Asano M, Ishida S, Murakami Y, Satake M, Ito Y, Shigesada K: Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol. 1990, 64 (10): 4808-4819.
PubMed
CAS
PubMed Central
Google Scholar
Levanon D, Groner Y: Structure and regulated expression of mammalian RUNX genes. Oncogene. 2004, 23 (24): 4211-4219. 10.1038/sj.onc.1207670.
Article
PubMed
CAS
Google Scholar
Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y: PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. . 1993, 90 (14): 6859-6863.
CAS
Google Scholar
Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA: Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993, 13 (6): 3324-3339.
Article
PubMed
CAS
PubMed Central
Google Scholar
Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y: Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. Embo J. 2001, 20 (4): 723-733. 10.1093/emboj/20.4.723.
Article
PubMed
CAS
PubMed Central
Google Scholar
Lutterbach B, Hiebert SW: Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene. 2000, 245 (2): 223-235. 10.1016/S0378-1119(00)00014-7.
Article
PubMed
CAS
Google Scholar
Osato M: Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene. 2004, 23 (24): 4284-4296. 10.1038/sj.onc.1207779.
Article
PubMed
CAS
Google Scholar
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C: New mechanisms of AML1 gene alteration in hematological malignancies. Leukemia. 2003, 17 (1): 9-16. 10.1038/sj.leu.2402766.
Article
PubMed
CAS
Google Scholar
Michaud J, Wu F, Osato M, Cottles GM, Yanagida M, Asou N, Shigesada K, Ito Y, Benson KF, Raskind WH, Rossier C, Antonarakis SE, Israels S, McNicol A, Weiss H, Horwitz M, Scott HS: In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis. Blood. 2002, 99 (4): 1364-1372. 10.1182/blood.V99.4.1364.
Article
PubMed
CAS
Google Scholar
Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM, Gilliland DG: Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet. 1999, 23 (2): 166-175. 10.1038/13793.
Article
PubMed
CAS
Google Scholar
Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki K, Kanno T, Shigesada K, Ito Y: Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood. 1999, 93 (6): 1817-1824.
PubMed
CAS
Google Scholar
Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Coignet L, Nucifora G: AML1 gene over-expression in childhood acute lymphoblastic leukemia. Leukemia. 2002, 16 (4): 658-668. 10.1038/sj.leu.2402399.
Article
PubMed
CAS
Google Scholar
Rhoades KL, Hetherington CJ, Harakawa N, Yergeau DA, Zhou L, Liu LQ, Little MT, Tenen DG, Zhang DE: Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood. 2000, 96 (6): 2108-2115.
PubMed
CAS
Google Scholar
Ford AM, Bennett CA, Price CM, Bruin MC, Van Wering ER, Greaves M: Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc Natl Acad Sci U S A. 1998, 95 (8): 4584-4588. 10.1073/pnas.95.8.4584.
Article
PubMed
CAS
PubMed Central
Google Scholar
Cook WD, McCaw BJ: Accommodating haploinsufficient tumor suppressor genes in Knudson's model. Oncogene. 2000, 19 (30): 3434-3438. 10.1038/sj.onc.1203653.
Article
PubMed
CAS
Google Scholar
Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR: AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996, 84 (2): 321-330. 10.1016/S0092-8674(00)80986-1.
Article
PubMed
CAS
Google Scholar
Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA: Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A. 1996, 93 (8): 3444-3449. 10.1073/pnas.93.8.3444.
Article
PubMed
CAS
PubMed Central
Google Scholar
North T, Gu TL, Stacy T, Wang Q, Howard L, Binder M, Marin-Padilla M, Speck NA: Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development. 1999, 126 (11): 2563-2575.
PubMed
CAS
Google Scholar
Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N, Groner Y: Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech Dev. 2001, 109 (2): 413-417. 10.1016/S0925-4773(01)00537-8.
Article
PubMed
CAS
Google Scholar
Lian JB, Balint E, Javed A, Drissi H, Vitti R, Quinlan EJ, Zhang L, Van Wijnen AJ, Stein JL, Speck N, Stein GS: Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo. J Cell Physiol. 2003, 196 (2): 301-311. 10.1002/jcp.10316.
Article
PubMed
CAS
Google Scholar
Planaguma J, Diaz-Fuertes M, Gil-Moreno A, Abal M, Monge M, Garcia A, Baro T, Thomson TM, Xercavins J, Alameda F, Reventos J: A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma. Cancer Res. 2004, 64 (24): 8846-8853. 10.1158/0008-5472.CAN-04-2066.
Article
PubMed
CAS
Google Scholar
Sakakura C, Hagiwara A, Miyagawa K, Nakashima S, Yoshikawa T, Kin S, Nakase Y, Ito K, Yamagishi H, Yazumi S, Chiba T, Ito Y: Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Int J Cancer. 2005, 113 (2): 221-228. 10.1002/ijc.20551.
Article
PubMed
CAS
Google Scholar
Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, Boer JM, Beverloo HB, Moorhouse MJ, van der Spek PJ, Lowenberg B, Delwel R: Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004, 350 (16): 1617-1628. 10.1056/NEJMoa040465.
Article
PubMed
CAS
Google Scholar
Albertini RJ, Hayes RB: Somatic cell mutations in cancer epidemiology. IARC Sci Publ. 1997, 159-184.
Google Scholar
Sankaranarayanan K, Wassom JS: Ionizing radiation and genetic risks XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic disorders. Mutat Res. 2005, 578 (1-2): 333-370.
Article
PubMed
CAS
Google Scholar
Michaud J, Kudoh J, Berry A, Bonne-Tamir B, Lalioti MD, Rossier C, Shibuya K, Kawasaki K, Asakawa S, Minoshima S, Shimizu N, Antonarakis SE, Scott HS: Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. Genomics. 2000, 68 (1): 71-79. 10.1006/geno.2000.6258.
Article
PubMed
CAS
Google Scholar
Ho Sui SJ, Mortimer JR, Arenillas DJ, Brumm J, Walsh CJ, Kennedy BP, Wasserman WW: oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes. Nucleic Acids Res. 2005, 33 (10): 3154-3164. 10.1093/nar/gki624.
Article
PubMed
PubMed Central
Google Scholar
Scherr M, Eder M: Modulation of gene expression by siRNA in hematopoietic cells. Curr Opin Drug Discov Devel. 2005, 8 (2): 262-269.
PubMed
CAS
Google Scholar
Smith ML, Arch R, Smith LL, Bainton N, Neat M, Taylor C, Bonnet D, Cavenagh JD, Andrew Lister T, Fitzgibbon J: Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3. Br J Haematol. 2005, 128 (3): 318-323. 10.1111/j.1365-2141.2004.05324.x.
Article
PubMed
CAS
Google Scholar
Cao W, Britos-Bray M, Claxton DF, Kelley CA, Speck NA, Liu PP, Friedman AD: CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells. Oncogene. 1997, 15 (11): 1315-1327. 10.1038/sj.onc.1201305.
Article
PubMed
CAS
Google Scholar
Strom DK, Nip J, Westendorf JJ, Linggi B, Lutterbach B, Downing JR, Lenny N, Hiebert SW: Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle. J Biol Chem. 2000, 275 (5): 3438-3445. 10.1074/jbc.275.5.3438.
Article
PubMed
CAS
Google Scholar
Jordan MA, Wilson L: Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004, 4 (4): 253-265. 10.1038/nrc1317.
Article
PubMed
CAS
Google Scholar
Pearson CG, Bloom K: Dynamic microtubules lead the way for spindle positioning. Nat Rev Mol Cell Biol. 2004, 5 (6): 481-492. 10.1038/nrm1402.
Article
PubMed
CAS
Google Scholar
Tanaka Y, Watanabe T, Chiba N, Niki M, Kuroiwa Y, Nishihira T, Satomi S, Ito Y, Satake M: The protooncogene product, PEBP2beta/CBFbeta, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures. Oncogene. 1997, 15 (6): 677-683. 10.1038/sj.onc.1201235.
Article
PubMed
CAS
Google Scholar
Lecine P, Italiano JE, Kim SW, Villeval JL, Shivdasani RA: Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 2000, 96 (4): 1366-1373.
PubMed
CAS
Google Scholar
Derry JM, Ochs HD, Francke U: Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell. 1994, 78 (4): 635-644. 10.1016/0092-8674(94)90528-2.
Article
PubMed
CAS
Google Scholar
Seri M, Cusano R, Gangarossa S, Caridi G, Bordo D, Lo Nigro C, Ghiggeri GM, Ravazzolo R, Savino M, Del Vecchio M, d'Apolito M, Iolascon A, Zelante LL, Savoia A, Balduini CL, Noris P, Magrini U, Belletti S, Heath KE, Babcock M, Glucksman MJ, Aliprandis E, Bizzaro N, Desnick RJ, Martignetti JA: Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium. Nat Genet. 2000, 26 (1): 103-105. 10.1038/79063.
Article
PubMed
CAS
Google Scholar
Dumontet C, Jaffrezou JP, Tsuchiya E, Duran GE, Chen G, Derry WB, Wilson L, Jordan MA, Sikic BI: Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization. Bull Cancer. 2004, 91 (5): E81-112.
PubMed
Google Scholar
Zaffaroni N, Pennati M, Colella G, Perego P, Supino R, Gatti L, Pilotti S, Zunino F, Daidone MG: Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer. Cell Mol Life Sci. 2002, 59 (8): 1406-1412. 10.1007/s00018-002-8518-3.
Article
PubMed
CAS
Google Scholar
Alcalay M, Meani N, Gelmetti V, Fantozzi A, Fagioli M, Orleth A, Riganelli D, Sebastiani C, Cappelli E, Casciari C, Sciurpi MT, Mariano AR, Minardi SP, Luzi L, Muller H, Di Fiore PP, Frosina G, Pelicci PG: Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair. J Clin Invest. 2003, 112 (11): 1751-1761.
Article
PubMed
CAS
PubMed Central
Google Scholar
Castilla LH, Garrett L, Adya N, Orlic D, Dutra A, Anderson S, Owens J, Eckhaus M, Bodine D, Liu PP: The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nat Genet. 1999, 23 (2): 144-146. 10.1038/13776.
Article
PubMed
CAS
Google Scholar
Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington CJ, Burel SA, Lagasse E, Weissman IL, Akashi K, Zhang DE: AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci U S A. 2001, 98 (18): 10398-10403. 10.1073/pnas.171321298.
Article
PubMed
CAS
PubMed Central
Google Scholar
Michaud J, Scott HS, Escher R: AML1 interconnected pathways of leukemogenesis. Cancer Invest. 2003, 21 (1): 105-136. 10.1081/CNV-120018821.
Article
PubMed
CAS
Google Scholar
Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M: AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998, 17 (18): 2287-2293. 10.1038/sj.onc.1202151.
Article
PubMed
CAS
Google Scholar
Bernardin-Fried F, Kummalue T, Leijen S, Collector MI, Ravid K, Friedman AD: AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression. J Biol Chem. 2004, 279 (15): 15678-15687. 10.1074/jbc.M310023200.
Article
PubMed
CAS
Google Scholar
Iwatsuki K, Tanaka K, Kaneko T, Kazama R, Okamoto S, Nakayama Y, Ito Y, Satake M, Takahashi S, Miyajima A, Watanabe T, Hara T: Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3. Oncogene. 2005, 24 (7): 1129-1137. 10.1038/sj.onc.1208287.
Article
PubMed
CAS
Google Scholar
Perretti M, Ahluwalia A, Harris JG, Goulding NJ, Flower RJ: Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J Immunol. 1993, 151 (8): 4306-4314.
PubMed
CAS
Google Scholar
Alldridge LC, Bryant CE: Annexin 1 regulates cell proliferation by disruption of cell morphology and inhibition of cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal. Exp Cell Res. 2003, 290 (1): 93-107. 10.1016/S0014-4827(03)00310-0.
Article
PubMed
CAS
Google Scholar
Levanon D, Glusman G, Bangsow T, Ben-Asher E, Male DA, Avidan N, Bangsow C, Hattori M, Taylor TD, Taudien S, Blechschmidt K, Shimizu N, Rosenthal A, Sakaki Y, Lancet D, Groner Y: Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1. Gene. 2001, 262 (1-2): 23-33. 10.1016/S0378-1119(00)00532-1.
Article
PubMed
CAS
Google Scholar
Chaussade C, Pirola L, Bonnafous S, Blondeau F, Brenz-Verca S, Tronchere H, Portis F, Rusconi S, Payrastre B, Laporte J, Van Obberghen E: Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol Endocrinol. 2003, 17 (12): 2448-2460. 10.1210/me.2003-0261.
Article
PubMed
CAS
Google Scholar
Smyth GK, Michaud J, Scott HS: Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics. 2005, 21 (9): 2067-2075. 10.1093/bioinformatics/bti270.
Article
PubMed
CAS
Google Scholar
Buckley MJ: Spot User's Guide. CSIRO Mathematical and Information Sciences, Sydney, Australia. 2000
Google Scholar
Smyth GK, Speed T: Normalization of cDNA microarray data. Methods. 2003, 31 (4): 265-273. 10.1016/S1046-2023(03)00155-5.
Article
PubMed
CAS
Google Scholar
Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP: Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 2003, 31 (4): e15-10.1093/nar/gng015.
Article
PubMed
PubMed Central
Google Scholar
Smyth GK: Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical Applications in Genetics and Molecular Biology. 2004, 3 (1): article 3-10.2202/1544-6115.1027.
Article
Google Scholar
Tian L, Greenberg SA, Kong SW, Altschuler J, Kohane IS, Park PJ: Discovering statistically significant pathways in expression profiling studies. Proc Natl Acad Sci U S A. 2005, 102 (38): 13544-13549. 10.1073/pnas.0506577102.
Article
PubMed
CAS
PubMed Central
Google Scholar
Kim SY, Volsky DJ: PAGE: parametric analysis of gene set enrichment. BMC Bioinformatics. 2005, 6: 144-10.1186/1471-2105-6-144.
Article
PubMed
PubMed Central
Google Scholar
Dinu I, Potter JD, Mueller T, Liu Q, Adewale AJ, Jhangri GS, Einecke G, Famulski KS, Halloran P, Yasui Y: Improving gene set analysis of microarray data by SAM-GS. BMC Bioinformatics. 2007, 8: 242-10.1186/1471-2105-8-242.
Article
PubMed
PubMed Central
Google Scholar
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005, 102 (43): 15545-15550. 10.1073/pnas.0506580102.
Article
PubMed
CAS
PubMed Central
Google Scholar
Hollander M, Wolfe DA: Nonparametric stitistical inference. 1973, New York , John Wiley & Sons, 27-33.
Google Scholar
Owen AB, Stuart J, Mach K, Villeneuve AM, Kim S: A gene recommender algorithm to identify coexpressed genes in C. elegans. Genome Res. 2003, 13 (8): 1828-1837.
PubMed
CAS
PubMed Central
Google Scholar
Beissbarth T, Speed TP: GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics. 2004, 20 (9): 1464-1465. 10.1093/bioinformatics/bth088.
Article
PubMed
CAS
Google Scholar
Verrills NM, Flemming CL, Liu M, Ivery MT, Cobon GS, Norris MD, Haber M, Kavallaris M: Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions. Chem Biol. 2003, 10 (7): 597-607. 10.1016/S1074-5521(03)00141-8.
Article
PubMed
CAS
Google Scholar