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Table 1 Gene ontology enrichment

From: Integrative analysis of RUNX1 downstream pathways and target genes

  FPD CBF E8.5 E12
GO: Biological processes Immune response p = 6.5 × 10 -5 36 genes Macromolecular complex assembly p = 0.02 47 genes Blood vessel development p = 0.06 15 genes Response to external stimulus* p = 0.0003 18 genes
  Negative regulation of apoptosis p = 0.002 16 genes Cell growth p = 0.02 21 genes   Behavior p = 0.0003 14 genes
  Response to biotic stimulus p = 0.002 19 genes    Immune system process p = 0.0006 18 genes
  Cell proliferation p = 0.01 36 genes    
GO: Molecular functions Cadmium ion binding p = 0.002 4 genes RNA binding p = 0.03 50 genes   IgG binding p = 0.006 3 genes
   Cadmium ion binding p = 0.03 4 genes   Ferric-chelate reductase activity p = 0.03 2 genes
     Polysaccharide binding p = 0.03 6 genes
GO: cellular component   Spindle p = 0.06 11 genes Cell junction p = 0.06 14 genes Cell surface p = 0.05 9 genes
     Extracellular space p = 0.06 37 genes
InterPro motifs (FatiGo) Vertebrate metallothionein p = 0.0001 Vertebrate metallothionein p = 0.02   
   Tubulin p = 0.04   
  1. The most significant gene ontology annotations are indicated for each dataset as identified through GOStat in April 2007. InterPro motifs were identified through the FatiGo program. The p-values are corrected for multiple testing (False discovery rate, Benjamini).