Figure 3

A comparison and analysis of D30 and 930918-3 variable genome content. In this figure, we illustrate the differential gene content of D30 and 930918-3 (Panel A) and compared the variable genome content of 1127 genes to all other completely sequenced S. aureus strains. Panel A depicts the differential gene content of D30 (red spots) and 930918-3 (blue spots) as mapped on to the staphylococcal pan-genome. The genes are represented in the array where the rows are named R1 through R72 and the columns are named C1 through C86 and each array element indexes a single gene (R#:C#). Panel B compares the combined variable gene content of strains D30 and 930918-3 to other 12 completely sequenced strains of S. aureus. The grayscale denotes the number of shared genes in the variable genome. The strain 930918-3 is the closest in variable gene content to D30, followed by strains NCTC8325 and USA300. This result is reminiscent of the MLST dendrogram (Figure 1) where these four strains were present on the same clade.