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Table 1 Effect of annotation and intensity based filters on the selection of TP and reduction of unspliced exon set (TN).

From: Dissecting an alternative splicing analysis workflow for GeneChip®Exon 1.0 ST Affymetrix arrays

  Splicing set Splicing set Splicing set
  128.32 vs 512 32.2 vs 128 2.0 vs 32
  TP
(Sensitivity)
TN
(Specificity)
TP
(Sensitivity)
TN
(Specificity)
TP
(Sensitivity)
TN
(Specificity)
Cross Hybridization filter 172
(1.00)
228264
(1.00)
195
(1.00)
228264
(1.00)
179
(1.00)
228264
(1.00)
Multiple mRNAs filter 172
(1.00)
71037
(0.31)
195
(1.00)
71037
(0.31)
179
(1.00)
71037
(0.31)
DABG filter
(DABG p-value ≤ 0.05 in 90% arrays)
172
(1.00)
197951
(0.86)
185
(0.95)
197951
(0.86)
170
(0.95)
197951
(0.86)
  1. The effects of filtering by means of annotation (Cross Hybridization/Multiple mRNAs filters) or intensity signal (DABG filter) are evaluated using exon-skipping events at various concentrations.