Table 1 HIV and influenza viral proteins. Some of the most important HIV and influenza viral proteins are listed with a brief description of their functions. They are listed by the order of their location in the corresponding virions [7–10].
From: Protein intrinsic disorder toolbox for comparative analysis of viral proteins
Major HIV proteins | ||
|---|---|---|
Protein | Function of the Protein | Location |
SU(gp120) | Binding of host's CD4 to itself | Virion Surface(SU) |
TM (gp41) | Involved in fusion with host | Transmembrane (TM) at the Virion Envelope |
MA (p17) | Matrix | Beneath the Enevelope |
Vpua | Virion release | Â |
Vpr | Nucleus transportation of viral proteins | Within capsid and beneath matrix |
CA (p24) | Main core protein | Nucleocapsid |
PR (p11) | Protease. | Within the Core |
RT (p66) | Reverse Transcriptase | Within th Core |
IN (p32) | Integrase. | Within the Core |
Tata | Transcription factor | NAa |
Major influenza A virus proteins | ||
Protein | Function/Description | Location |
HA | Hemagglutinin allows the attachhment of host's CD4 to itself | Envelope |
NA | Neuraminidase cleaves sialic acud group to allow virion release into the extracellular region. | Transmembrane (TM) at the Virion Envelope |
MA (M1, M2) | Protein assembly with membrane binding and disassociation | Matrix: Beneath the Enevelope |
NS1 | Non-Structural Protein. Inhibits RNA splicing. RNA binding | Within capsid and beneath matrix |
NS2 | Transportation of RNPb to cytoplasm | Â |
NP | Nucleoprotein | Nucleocapsid |
PB1 | Main core protein | Binds to Nucleocapsid |