Skip to main content
Figure 5 | BMC Genomics

Figure 5

From: Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing

Figure 5

Regulation of the cholesterol degradation pathway by IdeR, KstR and KstR2. Sequences similar to the IdeR binding boxes appear in the upstream regions of genes in the cholesterol degradation pathway in close proximity to (and sometimes overlapping with) the KstR and KstR2 binding regions. (A, B and C) Under either normal iron availability or lack of cholesterol either IdeR or KstR/KstR2 represses the expression of genes in this pathway. (D) Only under low iron availability (relieving IdeR repression) and in presence of cholesterol (relieving KstR and KstR2 repression), can the genes in the cholesterol degradation pathway be expressed.

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us