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Table 2 Induced THP-1 pathways upon M. bovis BCG infection

From: Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing

Pathway name

Number of genes annotated in pathway

Number of induced genes

P-value

IFN-α/β signaling

36

23

<1.0 × 10−5

IFN-γ signaling

28

16

<1.0 × 10−5

RIG-I/MDA5-mediated induction of IFN-α/β pathways

12

8

<1.0 × 10−5

Cytosolic DNA-sensing pathway

23

8

0.00018

Cholesterol biosynthesis

14

6

0.0033

Hepatitis C

71

14

0.00073

Staphylococcus aureus infection

11

5

0.00078

Steroid biosynthesis

11

5

0.00078

Iron uptake and transport

7

4

0.00096

Toxoplasmosis

60

12

0.00152

  1. The ten most significantly induced pathways are shown.