Fig. 5

Subgroup-specific molecular network characteristics for subgroup-5 and subgroup-1. Network modules consisting of significant differential altered genes of subgroup-5 (a) and subgroup-1 (b). The node size denotes the network propagation score from the NBS, showing the effect of genetic alterations in the biological network. The node color corresponds to different biological functional terms. The node labels of genes with significant mRNA expression changes (q-value < 0.05) in each subgroup compared to other patients are marked with green. Below the network module, four significantly differential expressed genes in this subgroup compared to the remaining ones are demonstrated for each subgroup. The significance of differential expressions of the altered genes was calculated using the Wilcoxon rank-sum test (with corrected q-value < 0.05). Similar settings were used for Fig. 6