Table 3 Genotypic distribution of candidate SNPs for LS in Lundehund dogs. Chi-square test results are shown for the four candidate SNPs chosen from filtering analysis for mutations predicted to have high or moderate effects. Genotypes are assigned to Lundehund without signs of LS (0), LS-affected Lundehund (1) and LS-suspicious dogs (1 susp.) due to clinical signs
CFA | Gene | Polymorphism | Chi-Square genotype (Probability) | Chi-Square allele (Probability) | Chi-Square trend (Probability) | LS status affected (1) or unaffected (0) | Genotype 0/0 (number and frequency) | Genotype 0/1 (number and frequency) | Genotype 1/1 (number and frequency) |
|---|---|---|---|---|---|---|---|---|---|
34 | LEPREL1 | LEPREL1:g.139212C>G | 6.807 (P = 0.033) | 4.959 (P = 0.026) | 4.293 (P = 0.038) | 0 | 1 (2.78) | 7 (19.44) | 7 (19.44) |
| Â | Â | Â | Â | Â | Â | 1 | 0 (0.00) | 0 (0.00) | 15 (41.70) |
| Â | Â | Â | Â | Â | Â | 1 (susp.) | 1 (2.78) | 2 (5.56) | 3 (8.34) |
5 | CEP164 | CEP164:g.57380G>T | 6.264 (P = 0.044) | 4.538 (P = 0.033) | 4.412 (P = 0.036) | 0 | 4 (11.43) | 6 (17.14) | 5 (14.29) |
| Â | Â | Â | Â | Â | Â | 1 | 0 (0.00) | 7 (19.46) | 7 (19.46) |
| Â | Â | Â | Â | Â | Â | 1 (susp.) | 0 (0.00) | 2 (5.56) | 4 (11.12) |
14 | COL28A1 | COL28A1:g.159951T>A | 0.614 (P = 0.736) | 0.019 (P = 0.889) | 0.021 (P = 0.883) | 0 | 3 (8.57) | 7 (20.00) | 5 (14.29) |
| Â | Â | Â | Â | Â | Â | 1 | 2 (5.72) | 8 (22.80) | 4 (11.44) |
| Â | Â | Â | Â | Â | Â | 1 (susp.) | 1 (2.86) | 4 (11.44) | 1 (2.86) |
27 | KRT3 | KRT3:g.2584C>T | 3.379 (P = 0.184) | 2.483 (P = 0.115) | 2.146 (P = 0.143) | 0 | 3 (8.33) | 8 (22.22) | 4 (11.11) |
| Â | Â | Â | Â | Â | Â | 1 | 3 (8.33) | 4 (11.12) | 8 (22.22) |
| Â | Â | Â | Â | Â | Â | 1 (susp.) | 0 (0.00) | 2 (5.56) | 4 (11.12) |