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Table 3 Genotypic distribution of candidate SNPs for LS in Lundehund dogs. Chi-square test results are shown for the four candidate SNPs chosen from filtering analysis for mutations predicted to have high or moderate effects. Genotypes are assigned to Lundehund without signs of LS (0), LS-affected Lundehund (1) and LS-suspicious dogs (1 susp.) due to clinical signs

From: Variant detection and runs of homozygosity in next generation sequencing data elucidate the genetic background of Lundehund syndrome

CFA Gene Polymorphism Chi-Square genotype (Probability) Chi-Square allele (Probability) Chi-Square trend (Probability) LS status affected (1) or unaffected (0) Genotype
0/0 (number and frequency)
Genotype
0/1 (number and frequency)
Genotype
1/1 (number and frequency)
34 LEPREL1 LEPREL1:g.139212C>G 6.807 (P = 0.033) 4.959 (P = 0.026) 4.293 (P = 0.038) 0 1 (2.78) 7 (19.44) 7 (19.44)
       1 0 (0.00) 0 (0.00) 15 (41.70)
       1 (susp.) 1 (2.78) 2 (5.56) 3 (8.34)
5 CEP164 CEP164:g.57380G>T 6.264 (P = 0.044) 4.538 (P = 0.033) 4.412 (P = 0.036) 0 4 (11.43) 6 (17.14) 5 (14.29)
       1 0 (0.00) 7 (19.46) 7 (19.46)
       1 (susp.) 0 (0.00) 2 (5.56) 4 (11.12)
14 COL28A1 COL28A1:g.159951T>A 0.614 (P = 0.736) 0.019 (P = 0.889) 0.021 (P = 0.883) 0 3 (8.57) 7 (20.00) 5 (14.29)
       1 2 (5.72) 8 (22.80) 4 (11.44)
       1 (susp.) 1 (2.86) 4 (11.44) 1 (2.86)
27 KRT3 KRT3:g.2584C>T 3.379 (P = 0.184) 2.483 (P = 0.115) 2.146 (P = 0.143) 0 3 (8.33) 8 (22.22) 4 (11.11)
       1 3 (8.33) 4 (11.12) 8 (22.22)
       1 (susp.) 0 (0.00) 2 (5.56) 4 (11.12)