- Erratum
- Open Access
Erratum to: Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism
Received: 30 August 2016
Accepted: 15 September 2016
Published: 22 September 2016
The original article was published in BMC Genomics 2016 17:695
Erratum
Inference accuracy, sensitivity, and specificity of pairwise and collective inference on simulated data. a–b The mean square error and AUC versus sample sizes using pairwise test (PW), logistic regression (LR), and the three methods of DDA (MF, PL, and EE). Simulated genotypes were generated for 10 SNPs with parameters h¯ y = (−1, −0.3), ¯ J = (0, 0.1), σ h = σ J = 0.2 (see Methods). c-d Analogous results for 20 SNPs with h¯ y = (−1, −1 + h), ¯ J = (0, J), and σ h = σ J = 0.2. We set h = 0.7, J = 0.5 for the first 4 SNPs and their interactions and h = J = 0 otherwise. e-f Sensitivity and specificity of disease-associated interaction pairs. Simulated data were generated with parameters h¯ = (−1, −1), ¯ J = (0.01, 0.01), σh = 0.1, σJ = 0.05 for m = 10 SNPs, except the interaction between the first two SNPs, for which we set ¯ J = (0.01, 0.11). Interaction p-values for all pairs were calculated either by PW or by regularization to determine λ∗ followed by the construction of null distribution under λ∗ (Additional file 5: Figure S4) for LR, PL, and EE. The distribution of p-values for the true causal interaction pair and those of non-causal pair (geometric mean) are shown in e and f, respectively. The dominant model was used in all cases
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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Reference
- Woo, et al. Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism. BMC Genomics. 2016;17:695. doi:10.1186/s12864-016-2871-3.View ArticlePubMedPubMed CentralGoogle Scholar
