Fig. 3

Comparison of topological domain calling methods subject to Hi-C contact matrix preprocessing by simple filtering or iterative correction (IC). The methods were assessed in terms of boundary overlap between replicates (a), change (%) in mean boundary overlap after matrix correction (b), change (%) in standard deviation of mean overlap across replicates after matrix correction (c) and number of identified topological domains per cell type (d). The different colors correspond to the different callers. Gradients of the same color are used for the different values of the same parameter, ranging from low (light color) to high (dark color) values. The TAD callers along with the corresponding parameter settings are presented in the legend. For this analysis all available read pairs were used