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Table 3 Predicted muscle-specific gene targets for the top-ranked miRNAs of cluster A and B

From: MicroRNA expression patterns in post-natal mouse skeletal muscle development

miR ID

Cluster

Highly predicted target

Moderately predicted target

Homology with human miRNA

mmu-miR-18a-5p

A

Pax7

 

hsa-miR-18a-5p

mmu-miR-31-5p

A

Pax3, Myf5, Pax7

 

hsa-miR-31-5p

mmu-miR-130b-3p

A

Myod1

 

hsa-miR-130b-3p

mmu-miR-199a-5p

A

Pax3

Pax7, Myod1

hsa-miR-199a-5p

mmu-miR-200c-3p

A

 

Myf5

hsa-miR-200c-3p

mmu-miR-224-5p

A

Myod1

Pax7

First nt different from hsa-miR-224-5p

mmu-miR-134-5p

B

Pax7

Myf5

hsa-miR-134-5p

mmu-miR-136-5p

B

Pax3

Myog

Last nt different from hsa-miR-136-5p

mmu-miR-214-3p

B

Pax7

Pax3

hsa-miR-214-3p

mmu-miR-296-5p

B

Pax7

 

hsa-miR-296-5p

  1. Muscle-specific gene targets for the top-ranked miRNAs of cluster A and B were predicted using the miRNA/gene prediction tool in miRwalk v.2.0 [22]. A target was considered as “highly predicted” when returned positive by at least 3/4 prediction software and as “moderately predicted” when returned positive by 2/4 prediction software. The last column displays the name of the corresponding human miRNA. All miRNAs identified in this study were perfectly or highly homologous between mouse and human