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Table 2 Linear regression analysis of child DNA methylation signal predicted by maternal BMI

From: Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity

Probe

Gene

Effect

Standard Deviation

P-Value*

Associated Pathology

cg21790991 a

FSTL1

0.005058

0.001776

0.0156

Obesity [65, 66]

Cg03218460

SORCS2

0.003025

0.001091

0.0165

Cardiovascular disease [67]

SORCS family associated with Type 1 and 2 Diabetes [67–70]

Cg23241637

ZNF804A

0.002443

0.00081

0.0143

Schizophrenia [71–75]

Cg04798490

SHANK2

0.002391

0.000787

0.0143

Autism [76–81]

cg01307483

NRF1

0.002344

0.000879

0.0172

Type 2 Diabetes [82–85]

cg19312314

CBS

0.001952

0.000813

0.0243

Cardiovascular Disease [86]

Homocystinuria [87–89]

cg14321859

DLC1

0.001801

0.00076

0.0243

Insulin-Pathway [90]

Hepatocellular Carcinoma [91–94]

cg03067613

ATP8B3

0.001547

0.000672

0.0253

Reproduction [95, 96]

Liver Disease [97]

cg11296553

CEP72

0.001159

0.000312

0.0041

Ulcerative colitis [86]

cg16509445

CRYL1

0.001091

0.000427

0.0204

Hepatocellular Carcinoma [98, 99]

Cg16344026

PPARGC1B

0.001021

0.000403

0.0204

Obesity [100–102]

Cg15354625

ODZ4

0.000932

0.000402

0.0253

Bipolar Disorder [103–105]

cg23836542

CHN2

−0.00081

0.000337

0.0243

Insulin-Pathway [106]

Type 2 Diabetes [107, 108]

cg07511564

NXPH1

−0.00135

0.00061

0.0295

Type 2 Diabetes [109, 110]

cg18799510

GRIN3A

−0.00171

0.000633

0.0172

Schizophrenia [111, 112]

Cg14996807

UNC13A

−0.00174

0.00048

0.0041

Amyotrophic lateral sclerosis [113–116]

Cg18431297

SORCS2

−0.00316

0.001079

0.0146

Cardiovascular disease [67]

SORCS family associated with Type 1 and 2 Diabetes [67–70]

  1. *Hochberg adjusted p-values noted
  2. aBolded CpG sites are associated with Obesity, Diabetes, and/or the Insulin-Pathway
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BMC Genomics

ISSN: 1471-2164

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