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Table 3 Carbon fixation proteins from the hydroxypropionate–hydroxybutyrate carbon fixation pathway in M. sedula and the homologous found in A. copahuensis genome

From: Genome analysis of the thermoacidophilic archaeon Acidianus copahuensis focusing on the metabolisms associated to biomining activities

  Metallosphaera sedula Acidianus copahuensis  
Gene name Uniprot ID ORF (aa) NCBI accession ORF (aa) E-value Aa identical positions (%) HhcR (position) Protein Function
HhcR A4YIR2 115 EZQ01893 115 1.00E-46 64   HhcR transcription factor
accA A4YD22 510 EZQ11106 507 0 78 + (−46) Acetyl-CoA/propionyl-CoA carboxylase, alpha subunit
accB A4YD23 167 EZQ11107 167 2.00E-84 64 - Acetyl-CoA/propionyl-CoA carboxylase, beta subunit
accC A4YGI1 524 EZQ11108 523 0 81 + (−53) Acetyl-CoA/propionyl-CoA carboxylase, gamma subunit
mcr A4YEN2 357 EZQ11004 356 0 82 ? (−274) Malonyl-CoA/succinyl-CoA reductase
msr A4YI81 314 EZQ04857 317 2.00E-174 75 + (−20) Malonate semialdehyde reductase
hpcS A4YGR1 661 EZQ11066 653 0 78 - 3-Hydroxypropionyl-CoA synthetase
acr A4YGN2 332 EZQ01730 333 0 76 + (−19) Acryloyl-CoA reductase
mce A4YEG2 140 EZQ10835 141 4.00E-71 70 + (−65) Methylmalonyl-CoA epimerase
mcmA A4YEG1 553 EZQ10834 550 0 83 ? (−242) Methylmalonyl-CoA mutase (catalytic subunit)
mcmB A4YIE3 155 EZQ04694 138 8.00E-75 78 + (−39) Methylmalonyl-CoA mutase (coenzyme B12-binding subunit)
ssr A4YGN0 360 EZQ01731 360 0 77 + (−41) Succinate semialdehyde reductase
hbcS1 A4YDR9 549 - - - - - 4-Hydroxybutyryl-CoA synthetase
hbcS2 A4YDT1 564 EZQ11368 559 0 58 - 4-Hydroxybutyryl-CoA synthetase
hbcS3 A4YGM8 472 EZQ01733 471 0 85 + (−37) 4-Hydroxybutyryl-CoA synthetase
hbcD A4YGC7 507 EZQ02033 506 0 75 + (−30) 4-Hydroxybutyryl-CoA dehydratase
ack A4YEH9 395 EZQ11076 396 0 71 + (−40) Acetoacetyl-CoA-ketothiolase
hbd2 A4YGM9 391 EZQ01732 388 0 72 + (−46) Probable 3-hydroxybutyryl-CoA dehydrogenase
hpcD-hbd A4YDS4 651 EZQ11226 661 0 49 + (−91) Bifunctional crotonyl-CoA hydratase/3-hydroxybutyryl-CoA dehydrogenase
  A4YI89 259 EZQ04864 257 2.00E-133 71 + (−15) 3-hydroxypropionyl-coenzyme A dehydratase
  1. The proteins are identified by their NCBI accession number (A. copahuensis) or Uniprot identification number (M. sedula). ORF (aa) indicates length of the open reading frame in amino acids, E-values and amino acid identities were obtained by BLASTP analysis. The presence of the HhcR regulatory motifs in A. copahuensis at the promoter of each gene was determined following the procedures described by Leyn et al. 2015 [53]. Presence is indicated with (+), absence by (−) and cases where it was found more distant than average, with (?), and positions upstream the start codon are indicated in parenthesis. Aa: amino acids