Fig. 6

A co-localized and co-expressed gene set containing ACACA and TADA2A. a Syntenic region conserved between chicken, human and mouse. b Hepatic expression of the syntenic genes in the two diets and genotypes for male broiler chickens. c Correlation between TADA2A hepatic expression (taken as reference) and hepatic expression of other co-localized genes in two chicken experimental designs. Top: male broilers analyzed in this study (n = 48); bottom: female layers analyzed by RNA-Seq (n = 40). Rpkm normalized expression are available in the Additional file 5. d Expression in liver (Liv) and brain (Br) of C57BL/6 J mice (n = 22) (GDS3232 in GEO profiles [31]. e Circle plot depicting the correlation between TADA2A and the 298 down-regulated genes in HF diet: red edges indicate genes which expressions are highly correlated to TADA2A expression (r > =0.8). Red names indicate genes involved in lipid metabolism. Correlations in bold in the Figure (r > 0.7) are highly significant with a p-value ≤0.001