Table 2 Most dysregulated genes after late RAR inhibition. The top 20 decreased (left) and top 20 increased (right) genes after RAR inhibition during the early treatment window
From: Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function
Decreased | Increased | ||
|---|---|---|---|
Gene | Full Name | Gene | Full Name |
CYP26A1 | cytochrome P450 family 26, subfamily A, member 1 | FRZB | frizzle-related protein |
DHRS3 | dehydrogenase/reductase 3 | HBD | hemoglobin subunit delta |
COCH | cochlin | VSX1 | visual system homeobox 1 |
CRABP2 | cellular retinoic acid binding protein 2 | CAPN3 | calpain 3 |
ALX4 | ALX homeobox 4 | SLC39A8 | solute carrier family 39 member 8 |
GATA2 | GATA binding protein 2 | SMOC1 | SPARC related modular calcium binding 1 |
SIX2 | SIX homeobox 2 | SIM2 | single-minded family bHLH transcription factor 2 |
HIC1 | HIC ZBTB transcriptional repressor 1 | CHODL | chondrolectin |
RARB | retinoic acid receptor beta | DLX2 | distal-less homeobox 2 |
SSTR2 | somatostatin receptor 2 | MIP | major intrinsic protein of lens fiber |
HAS2 | hyaluronan synthase 2 | PMP2 | peripheral myelin protein 2 |
TGFBI | transforming growth factor beta induced | PCK2 | phosphoenolpyruvate carboxykinase 2, mitochondrial |
CYP26B1 | cytochrome P450 family 26, subfamily B, member 1 | HEMGN | hemogen |
SFRP1 | secreted frizzled related protein 1 | LHX1 | LIM homeobox 1 |
BMP5 | bone morphogenetic protein 5 | IFGBP2 | insulin like growth factor binding protein 2 |
BGN | biglycan | AIFM3 | apoptosis inducing factor, mitochondria associated 13 |
GATA3 | GATA binding protein 3 | ATOH7 | atonal bHLH transcription factor 7 |
GH1 | growth hormone 1 | CRYBG1 | crystallin beta-gamma domain containing 1 |
DNAJC12 | DnaJ heat shock protein family (Hsp40) member C12 | ERMIN | ermin |
RHBG | Rh family B glycoprotein | CLUL1 | clusterin like 1 |