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Fig. 1 | BMC Genomics

Fig. 1

From: Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics

Fig. 1

The steps to conduct gene-metabolite investigation. Abbreviation: SEM: structural equation modeling; CCRS: convex-concave rare variant selection; G-DAG: genome directed acyclic graph. Details of the CCRS method (for the genome analysis) and the steps of the G-DAG algorithm (for constructing metabolomics causal networks) are described in the methods section

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